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| Expression and Clinical Significance of Supervillin and IL-1β Proteins in Epithelial Ovarian Cancer Tissues |
| LIU Yu, CHEN Ying |
| Department of Gynecology,the Fourth Affiliated Hospital of China Medical University,Shenyang Liaoning 110032 |
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Abstract 【Objective】 To investigate the expression and clinical significance of Supervillin(SVIL) and interleukin-1β(IL-1β) proteins in epithelial ovarian cancer(EOC) tissues. 【Methods】 A total of ovarian epithelial tumor tissue specimens resected surgically and confirmed by pathological examination in our hospital from January 2010 to June 2022 were selected, including 40 cases of EOC tissue specimens(group A), 20 cases of ovarian epithelial borderline tumor tissue specimens(group B) and 20 cases of ovarian epithelial benign tumor tissue specimens(group C). Immunohistochemistry was used to detect the expression levels of SVIL and IL-1β proteins in each group, and their clinical significance was analyzed. 【Results】 Immunohistochemical results showed that the positive expression rates of SVIL and IL-1β proteins in group A and group B were significantly higher than those in group C, with statistically significant differences(P<0.05), while there were no statistically significant differences in the positive expression rates of SVIL and IL-1β proteins between group A and group B(P>0.05). The positive expression rates of SVIL and IL-1β proteins in EOC tissues were correlated with the degree of tissue differentiation and clinical stage(P<0.05), but not significantly correlated with age, histological type, presence of ascites and presence of lymph node metastasis(P>0.05). The expression of SVIL protein was positively correlated with that of IL-1β protein in EOC tissue specimens(r=0.373, P=0.018).【Conclusion】 SVIL and IL-1β proteins may be involved in the occurrence and development of EOC, and there is a significant correlation between them.
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Received: 12 July 2024
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2026, Vol. 43 
