血清抗β2糖蛋白1抗体水平与老年H型高血压患者颈动脉粥样硬化斑块稳定性的相关性

doi:10.3969/j.issn.1671-7171.2025.04.019

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1204 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To explore the correlation between serum anti-β 2 glycoprotein 1 antibody (aβ2GP1) and the stability of carotid atherosclerotic plaques in elderly patients with H-type hypertension. 【Methods】 A total of 124 elderly patients with H-type hypertension admitted to our hospital from August 2019 to October 2023 were selected. According to the results of carotid ultrasound examination, the patients were divided into the unstable plaque group (n=69) and the stable plaque group (n=55). Logistic regression analysis was used to explore the risk factors influencing the stability of carotid atherosclerotic plaques in elderly patients with H-type hypertension. The receiver operating characteristic (ROC) curve was fabricated to analyze the predictive value of serum aβ2GP1 level for unstable carotid atherosclerotic plaques in elderly patients with H-type hypertension. 【Results】 The levels of homocysteine, C-reactive protein, tumor necrosis factor-α, interleukin-1β, aβ2GP1 and IMT in the unstable plaque group were higher than those in the stable plaque group, and the difference was statistically significant (P<0.05). Logistic multifactor regression analysis showed that Hcy, aβ2GP1 all affected the elderly H-type hypertensive patients with carotid atherosclerotic plaque stability related factors (P<0.05). ROC curve analysis showed that the optimal cutoff point of serum aβ2GP1 for predicting carotid atherosclerotic unstable plaques in elderly patients with H-type hypertension was 15.24 RU/mL, with sensitivity and specificity of 72.46% and 83.64% respectively, and the area under the curve was 0.831 (95%CI: 0.753-0.892). 【Conclusion】The level of serum aβ2GP1 is related to the stability of carotid atherosclerotic plaques in elderly patients with H-type hypertension, and the level of serum aβ2GP1 can be used as an important reference indicator for predicting the stability of carotid atherosclerotic plaques in elderly patients with H-type hypertension.

Key words： Hypertension Beta 2-GlycoproteinⅠ Antibodies Plaque Atherosclerotic

Received: 13 December 2024

PACS:

R544.1

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHOU Qian
	ZHANG Jinwei

Cite this article:

ZHOU Qian,ZHANG Jinwei. The Correlation between Serum Anti-β 2 Glycoprotein 1 Antibody Levels and the Stability of Carotid Atherosclerotic Plaques in Elderly Patients with H-Type Hypertension[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(4): 626-629.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.04.019 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I4/626

[1] 欧永强, 王维箭, 赵鹏. 血清同型半胱氨酸水平与H型高血压伴颈动脉粥样硬化患者炎症反应及斑块稳定性的关系[J].中国老年学杂志, 2019, 39(15):3614-3617.
[2] LI T, LIU X Y, DIAO S S, et al. H-type hypertension is a risk factor for cerebral small-vessel disease[J].Biomed Res Int,2020,18(23):903-906.
[3] 陶晓明, 李爽, 周冰峰, 等. 抗心磷脂抗体、抗β2糖蛋白1抗体、hs-CRP及同型半胱氨酸与老年脑梗死的相关性分析[J].中国老年学杂志, 2021, 41(20):4353-4357.
[4] 李建平, 卢新政, 霍勇, 等. H型高血压诊断与治疗专家共识[J].中国医学前沿杂志(电子版), 2016, 8(5):23-28.
[5] 张红菊, 王浩, 郭忆, 等. 北京社区人群颈动脉粥样硬化的分布特征及超声检查方法学标准化探讨[J].中国超声医学杂志, 2011, 27(9):811-814.
[6] 谢青, 范海燕. 人类软骨糖蛋白-39水平与颈动脉粥样硬化斑块及其稳定性的临床观察[J].检验医学与临床,2022,28(14):1914-1915.
[7] QIAO J, ZHOU K C, HUANG C, et al. Comparison of serum Lp-PLA2 levels in ischemic stroke patients with H-type hypertension or non-H-type hypertension[J].J Clin Lab Anal,2020,34(2):68-72.
[8] 许金鹏, 刘洋, 李靖, 等. H型高血压合并颈动脉粥样硬化患者血清Hcy含量与炎症因子、斑块稳定性的相关性[J].中国现代医学杂志, 2017, 27(28):61-65.
[9] 刘传亮, 李蕾, 伦雪洁. 老年H型高血压患者血清MMP-9、Hcy水平与颈动脉粥样硬化的相关性研究[J].世界最新医学信息文摘, 2020, 20(60):8-10.
[10] ZHOU F, HOU D, WANG Y K, et al. Evaluation of H-type hypertension prevalence and its influence on the risk of increased carotid intima-media thickness among a high-risk stroke population in Hainan province, China[J].Medicine(Baltimore),2020, 99(35):953-958.
[11] 程娟, 陈礼文, 唐伟, 等.抗心磷脂抗体及抗β2糖蛋白1抗体检测血脂正常脑梗死患者的临床意义[J].检验医学与临床, 2019, 16(9):1187-1190.
[12] DEMIR S, LI J, MAGDER L S, et al. Antiphospholipid patterns predict risk of thrombosis in systemic lupus erythematosus[J].Rheumatology,2021, 60(8):3770-3777.
[13] YUN J, GU J, KIM H K. Double positivity of anti-beta2-glycoprotein Ⅰ domain Ⅰ and anti-phosphatidylserine/prothrombin antibodies enhances both thrombosis and positivity of anti-ADAMTS13 antibody[J].J Thromb Thrombolysis,2021, 52(4):1133-1136.
[14] 王金玲, 刘霞, 王培昌. 抗心磷脂抗体与抗β2糖蛋白1抗体在2型糖尿病微血管病变中的意义[J].国际检验医学杂志, 2018, 39(18):2246-2248.