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| The Clinical Effect of Lithium Carbonate Sustained-Release Tablets Combined with Magnesium Valproate Sustained-release Tablets in the Treatment of Manic Episodes of Bipolar Disorder and its Influence on the Cognitive Function of Patients |
| ZHOU Jian |
| the Second People's Hospital of Shangqiu, Shangqiu Henan 476000 |
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Abstract 【Objective】To explore the clinical effect of lithium carbonate sustained-release tablets combined with magnesium valproate sustained-release tablets in the treatment of manic episodes of bipolar disorder and its influence on the cognitive function of patients.【Methods】One hundred patients with manic episodes of bipolar disorder admitted to our hospital from March 2022 to March 2024 were selected and divided into the control group and the observation group according to the random number table method, with 50 cases in each group. The control group was treated with lithium carbonate sustained-release tablets, while the observation group was treated with lithium carbonate sustained-release tablets combined with magnesium valproate sustained-release tablets. The clinical efficacy, cognitive function [Montreal Cognitive Assessment Scale (MoCA) score], degree of mania [Beck and Raffenson Mania Scale (BRMS) score], laboratory indicators [thyroid hormone (TH), thyroid stimulating hormone (TSH), adrenocorticotropic hormone (ACTH), cortisol (Cor)], and incidence of adverse reactions were compared between the two groups. 【Results】After treatment, the total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). After treatment, the MoCA scores of both groups were higher than those before treatment, and the BRMS scores were lower than those before treatment. Moreover, the MoCA score of the observation group was higher than that of the control group, and the BRMS score was lower than that of the control group. The differences were statistically significant (P<0.05). After treatment, the levels of serum TH, ACTH and Cor in both groups were lower than those before treatment, and the level of TSH was higher than that before treatment. The levels of serum TH, ACTH and Cor in the observation group were lower than those in the control group, and the level of TSH was higher than that in the control group. The differences were statistically significant (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the observation group and the control group (P>0.05). 【Conclusion】The combination of lithium carbonate sustained-release tablets and magnesium valproate sustained-release tablets has a good clinical efficacy in the treatment of manic episodes of bipolar disorder. It can improve cognitive function and manic symptoms, regulate neuroendocrine function, and has good safety.
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Received: 18 November 2024
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2025, Vol. 42 
