Abstract 【Objective】To investigate the expression and diagnostic value of endothelial cell-specific molecule-1 (Endocan) and Galectin-3 in the serum of patients with microvascular angina (CMSA). 【Methods】A total of 87 CMSA patients treated at Yanji County People's Hospital were selected as the observation group, while 87 healthy individuals during the same period were selected as the control group. The relevant data and serum Endocan and Galectin-3 expression levels of the two groups were compared. Logistic multivariate regression analysis was used to analyze the influencing factors of CMSA. The diagnostic value of serum Endocan and Galectin-3 levels for CMSA was evaluated by the area under the receiver operating characteristic (ROC) curve (AUC). 【Results】The proportions of diabetes, hypertension, and high levels of fasting blood glucose, serum Endocan and Galectin-3 in the observation group were higher than those in the control group (P<0.05). Logistic multivariate regression analysis showed that increased levels of diabetes, hypertension, fasting blood glucose, serum Endocan, and Galectin-3 were risk factors for CMSA (P<0.05). ROC analysis showed that the AUC of serum Endocan, Galectin-3, and their combined detection for diagnosing CMSA were 0.731, 0.785, and 0.891, respectively. 【Conclusion】There is a high expression of serum Endocan and Galectin-3 in CMSA patients, and the diagnostic valueefficacy of serum Endocan and Galectin-3 in CMSA is high.
CHEN Jing,WANG Yongqiang,LIU Meng. Expression and Diagnostic Value of Endocan and Galectin-3 in Serum of Patients with Microvascular Angina[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(7): 1041-1043.
2024, Vol. 41 
