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| Changes and Clinical Significance of Coagulation Function in Severe Preeclamps Complicated with HELLP Syndrome |
| HU Xiuling |
| Department of Obstetrics,Tianjin Jizhou District People's Hospital,Tianjin 301900 |
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Abstract 【Objective】To analyze the changes of coagulation function and its clinical significance in patients with severe preeclampsia (SPE) complicated with HELLP syndrome. 【Methods】Ninety-eight SPE patients admitted to our hospital from January 2018 to December 2022 were selected and divided into group A (with HELLP syndrome, n=30) and group B (without HELLP syndrome, n=68) according to whether the patients would develop HELLP syndrome during hospitalization. Coagulation indexes [fibrinogen (FIB), prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen degradation product (FDP), D-dimer (D-D)], interleukin (IL-6) and C-reactive protein (CRP) were compared between the two groups at admission. Multiple Logistic regression was used to analyze the influencing factors of SPE complicated with HELLP syndrome.【Results】There were no significant differences in pregnant type, age, gestational week, body weight, respiratory rate (RR), systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), mean arterial pressure (MAP), creatinine (Scr) and blood urea nitrogen (BUN) between the two groups (P>0.05). The PT and APTT measurements in group A were longer than those in group B, the levels of D-D, FDP, IL-6 and CRP were higher than those in group B, and the levels of FIB and red blood cell (RBC) count were lower than those in group B, with statistical significance (P<0.05). Multivariate Logistic regression analysis showed that PT, APTT, D-D, FDP, FIB and RBC were the influencing factors of HELLP syndrome in SPE patients (P<0.05). 【Conclusion】Abnormal RBC, PT, APTT, FIB, D-D and FDP are risk factors for HELLP syndrome in SPE patients. Monitoring the changes of the above indexes can provide references for clinicians to evaluate the condition, efficacy and prognosis of SPE patients with HELLP syndrome.
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Received: 30 January 2024
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2024, Vol. 41 
