依达拉奉右崁醇注射液联合氯吡格雷治疗老年急性脑梗死患者的疗效

doi:10.3969/j.issn.1671-7171.2024.06.018

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Abstract 【Objective】To explore the effectiveness of a combination of Etaracog Alfa injection and clopidogrel in treating elderly patients with acute cerebral infarction(ACI). 【Methods】A total of 82 elderly ACI patients treated were randomly divided into an observation group and a control group, with 41 patients in each group. The control group received clopidogrel treatment, while the observation group was treated with a combination of Etaracog Alfa injection and clopidogrel. The effectiveness of the treatments was compared by measuring various factors before and 14 days after treatment. These included the average blood flow velocity during systole(V_m) and peak blood flow(V_s) in the posterior cerebral artery, resistance index(RI), National Institutes of Health Stroke Scale(NIHSS) scores, and levels of high-sensitivity C-reactive protein(hs-CRP), tumor necrosis factor-alpha(TNF-α), glutathione peroxidase(GPx), and malondialdehyde(MDA). 【Results】 The total effective rate in the observation group was 95.12%(39/41), which was significantly higher than the 80.49%(33/41) in the control group(P<0.05). After treatment, V_m, V_s, and GPx levels were elevated in both groups, with higher increases in the observation group(P<0.05). RI, NIHSS scores, and levels of hs-CRP, TNF-α, and MDA were reduced compared to pre-treatment levels, with greater reductions in the observation group(P<0.05). 【Conclusion】 The combination of Etaracog Alfa injection and clopidogrel in treating elderly ACI patients effectively improves cerebral hemodynamics, inhibits inflammatory stress damage, restores neurological function, and is effective and safe overall.

Key words： Brain Infarction/DT Acute Disease Edaravone/TU Clopidogrel/TU Hemodynamics

Received: 20 December 2023

PACS:

R743.33

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	HAN Shasha
	XIE Pengfang
	LI Ning
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Cite this article:

HAN Shasha,XIE Pengfang,LI Ning, et al. Effectiveness of Etaracog Alfa Combined with Clopidogrel in Treating Elderly Patients with Acute Cerebral Infarction[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(6): 864-867.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.06.018 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I6/864

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