|
|
|
| The Predictive Value of Carbon Dioxide Ventilation Equivalent Intercept, C3a, and Inflammatory Factor Levels for the Risk of Disease Exacerbation in COPD Patients |
| WANG Long, CHEN Yu, ZHAO Ke |
| Department of Respiratory and Critical Care Medicine ,Anyang City People's Hospital, Anyang Henan 455000 |
|
|
|
|
Abstract 【Objective】 To explore the predictive value of carbon dioxide ventilation equivalent intercept, C3a, and inflammatory factor levels on the risk of disease exacerbation in patients with chronic obstructive pulmonary disease(COPD). 【Methods】A total of 100 patients diagnosed with COPD for the first time in our hospital from February 2020 to February 2023 were selected and followed up for 1 year. COPD patients were divided into two groups based on the number of disease exacerbations: recombinant group(disease exacerbation≥2 times/year, n=65) and stable group(disease exacerbation<2 times/year, n=35). The carbon dioxide ventilation equivalent intercept, C3a level, inflammatory factors [interleukin-6(IL-6), tumor necrosis factor-α(TNF-α), and C-reactive protein(CRP)] levels were compared between the two groups. The predictive value of carbon dioxide ventilation equivalent intercept, C3a, and inflammatory factor levels on the risk of exacerbation of COPD was analyzed using receiver operating characteristic(ROC) curves and logistic regression.【Results】 The proportion of smoking, carbon dioxide ventilation equivalent intercept, and levels of IL-6, TNF-α, and CRP in the control group were all higher than those in the stable group, while serum C3a levels were lower than those in the stable group, with statistical significance(P<0.05). The ROC curve analysis results showed that the area under the curve(AUC) for carbon dioxide ventilation equivalent intercept, C3a, IL-6, TNF-α, CRP, and combined prediction of the risk of exacerbation of COPD were 0.786, 0.746, 0.851, 0.848, 0.833, and 0.975, respectively. The results of the logistic regression model analysis showed that high carbon dioxide ventilation equivalent intercept, low serum C3a levels, and high levels of inflammatory factors were independent risk factors for exacerbation of COPD(P<0.05). 【Conclusion】Carbon dioxide ventilation equivalent intercept, serum C3a, and inflammatory factor levels have certain predictive value for the risk of exacerbation of COPD.
|
|
Received: 27 July 2023
|
|
|
|
|
|
[1] 王凤燕,王凌伟,杨宇琼,等. 慢性阻塞性肺疾病年度研究进展(2018—2019)[J].中华结核和呼吸杂志,2019,42(11):858-861.
[2] 刘志贞,陈思洋,付瑜. 患与不患慢性阻塞性肺疾病的吸烟者血清胆红素水平的差异[J].中国乡村医药,2021,28(18):3-4.
[3] 李芳,吴成明,程玉峰. 丙酸氟替卡松联合特布他林治疗慢性阻塞性肺疾病急性加重期患者的临床疗效及其对免疫功能、炎性反应的影响研究[J].实用心脑肺血管病杂志,2021,29(3):91-95.
[4] 王韶,曾玉琴,宋庆,等. 稳定期慢性阻塞性肺疾病患者初始药物治疗现状分析[J].医学临床研究,2022,39(10):1441-1444.
[5] 梁振宇,王凤燕,陈子正,等. 2023年GOLD慢性阻塞性肺疾病诊断、管理及预防全球策略更新要点解读[J].中国全科医学,2023,26(11):1287-1298.
[6] 郝倩文,张薇,孙美琪,等. 慢性阻塞性肺疾病生物学标志物的研究进展[J].医学综述,2021,27(2):264-268.
[7] 姜宗良,王海播,王语嫣,等. 慢性阻塞性肺疾病急性发作期患者就医延迟行为的现象学研究[J].中国全科医学,2020,23(27):3396-3401.
[8] 梁世锋. 盐酸唑酮片对慢性阻塞性肺疾病吸烟患者戒烟效果及生活质量的影响[J].齐齐哈尔医学院学报,2017,38(6):634-635.
[9] 宋燕新,刘萍,赵威. 分钟通气量和二氧化碳生成量关系对于心力衰竭患者的价值[J].心血管病学进展,2022,43(5):419-422.
[10] 于菲,侯玮,孙娟,等. 慢性阻塞性肺疾病合并肺部感染患者血浆C3、C4、PCT、免疫球蛋白水平的变化及易感因素分析[J].海南医学,2022,33(19):2452-2455.
[11] 李红英,刘华之. 慢性阻塞性肺疾病患者巨噬细胞刺激蛋白与炎症因子水平及肺功能的关系研究[J].检验医学与临床,2020,17(17):2520-2523.
[12] 陈圣琦,宋佳芳,史洪昊,等. 慢性阻塞性肺疾病患者用药模式识别评价和医疗费用分析[J].临床药物治疗杂志,2020,18(4):30-34.
[13] 袁玮,聂姗,贾楠,等. 二氧化碳通气当量截距与慢性阻塞性肺疾病进展的预测因子分析[J].心肺血管病杂志,2022,41(7):773-778.
[14] 张筱骞. 支气管哮喘患者血清TSLP、C3a和MMP-9水平测定及临床价值探讨[J].中国现代医生,2020,58(19):43-46.
[15] 卞庆平. 噻托溴铵联合舒利迭对中重度COPD患者炎症因子、血气指标及肺功能的影响[J].临床肺科杂志,2019,24(1):58-60. |
|
|
|
2024, Vol. 41 
