术前血清Lp-PLA2与NLRP3水平对IABP辅助PCI治疗的高危冠心病患者发生MACE的预测价值

doi:10.3969/j.issn.1671-7171.2024.05.016

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Abstract 【Objective】To explore the predictive value of preoperative serum lipoprotein associated phospholipase A2 (Lp-PLA2) and nucleotide binding oligomeric domain like receptor protein 3 (NLRP3) levels for cardiovascular adverse events (MACE) in high-risk coronary heart disease patients undergoing intra-aortic balloon counterpulsation (IABP) assisted percutaneous coronary intervention (PCI).【Methods】A total of 120 high-risk coronary heart disease patients admitted to our hospital were selected and all underwent IABP assisted PCI treatment. The incidence of MACE within 6 months after surgery was statistically analyzed and divided into the non MACE group and the MACE group. The preoperative serum Lp-PLA2 levels were compared between the two groups NLRP3 level. The correlation between preoperative serum Lp-PLA2 and NLRP3 levels and the degree of coronary stenosis were analyzed. The receiver operating characteristic (ROC) curve was used to analyze the value of preoperative serum Lp-PLA2 and NLRP3 level in predicting postoperative MACE.【Results】The incidence of MACE in 120 high-risk coronary heart disease patients after IABP assisted PCI was 34.17% (41/120); Preoperative serum Lp-PLA2 in the MACE group The levels of NLRP3 were higher than those in the non MACE group (P<0.05). Spearman correlation analysis showed that preoperative serum Lp-PLA2 The level of NLRP3 was positively correlated with the degree of coronary stenosis (r_s=0.750, 0.815, all P<0.05). The level of preoperative serum Lp-PLA2 and NLRP3 in severe patients was higher those in moderate and mild patients, with moderate patients having higher levels than mild patients (P<0.05). ROC curve analysis showed that the area under the curve predicted by preoperative serum Lp-PLA2 and NLRP3 level alone was 0.770 and 0.844, respectively. The joint prediction of AUC by the two was 0.909 (P<0.05).【Conclusion】The level of Preoperative serum Lp-PLA2 and NLRP3 was positively correlated with the degree of coronary artery stenosis in high-risk coronary heart disease patients. The combined detection of the two can provide a certain reference for clinical prediction of MACE in high-risk coronary heart disease patients after IABP assisted PCI surgery.

Key words： Coronary Disease 1-Alkyl-2-acetylglycerophosphocholine Esterase/BL NLR Family, Pyrin Domain-Containing 3 Protein/BL Percutaneous Coronary Intervention

Received: 30 June 2023

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R541.4

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	WANG Tao
	ZOU Yonghui
	YANG Lei

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WANG Tao,ZOU Yonghui,YANG Lei. The Predictive Value of Preoperative Serum Lp-PLA2 and NLRP3 Levels for MACE in High-Risk Coronary Heart Disease Patients Treated with IABP Assisted PCI[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(5): 700-703.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.05.016 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I5/700

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