|
|
|
| The Effect of Injecting NGF into Different Parts of the Body on the Hearing and Symptoms of Patients with Sudden Deafness |
| CHAI Xiaoxia, LIU Yujuan |
| Hancheng People's Hospital, Hancheng Shaanxi 715400 |
|
|
|
|
Abstract 【Objective】To explore the effects of injecting rat nerve growth factor (NGF) into different parts of the body on the hearing and symptoms of patients with sudden deafness. 【Methods】 A total of 70 patients with sudden deafness admitted to the Hancheng People's Hospital from October 2019 to October 2022 were randomly divided into an observation group and a control group, with 35 cases in each group, using a random number table method. The control group received NGF injection into the buttocks, while the observation group received NGF injection under the periosteum of the mastoid process behind the ear. We compared the clinical efficacy, incidence of adverse reactions, disappearance time of clinical symptoms (including tinnitus, ear tightness, and dizziness), and hearing threshold values (including bone conduction and air conduction hearing thresholds) before and after treatment between two groups of patients. 【Results】The total effective rate of clinical efficacy in the observation group was 94.29%, significantly higher than the control group's 74.29%, and the difference was statistically significant (P<0.05). The disappearance time of tinnitus, ear tightness, and dizziness in the observation group was shorter than that in the control group, and the difference was statistically significant (P<0.05). After treatment, the bone conduction and air conduction hearing thresholds of the two groups of patients were lower than before treatment, and the difference was statistically significant (P<0.05); After treatment, the bone conduction and air conduction hearing thresholds in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups of patients (P>0.05).【Conclusion】Compared with the injection of NGF into the buttocks, the injection of NGF into the subperiosteal area behind the ear and mastoid process has better clinical efficacy in the treatment of sudden deafness, with more significant improvement in clinical symptoms, promotion of hearing recovery, and higher safety.
|
|
Received: 30 December 2022
|
|
|
|
|
|
[1] ISLAMOGLU Y, KESICI G G, ERCAN K, et al. Single-sided deafness after sudden hearng loss: late effect on cochlear nerve size[J].Eur Arch Otorhinolaryngol,2020, 277(6):2423-2426.
[2] 李红,祝康,袁婕,等.经鼓膜穿刺与肌肉注射鼠神经生长因子对突发性耳聋的治疗效果对比[J].现代生物医学进展,2019,19(13):2453-2456.
[3] 冯彪, 程随涛, 秦萍. 鼠神经生长因子联合甲泼尼龙治疗突发性耳聋的临床分析[J].徐州医学院学报, 2019, 39(10):767-770.
[4] 漆可,曹春婷.经咽鼓管途径鼓室内灌注给药对突发性耳聋的挽救治疗观察[J].中国听力语言康复科学杂志,2021,19(2):146-148.
[5] 中华耳鼻咽喉头颈外科杂志编辑委员会,中华医学会耳鼻咽喉头颈外科学分会. 突发性聋诊断和治疗指南(2015)[J].中华耳鼻咽喉头颈外科杂志,2015,50(6):443-447.
[6] 刘小会.不同类型突发性耳聋患者疗效的影响因素[J].医学临床研究,2020,37(7):1079-1081.
[7] 严孝花,李戍军,韩宁,等.不同类型营养神经药物治疗突发性聋的比较评价研究[J].西南国防医药,2021,31(2):127-131.
[8] 王淑芳,张莉,张雯雯,等. 鼠神经生长因子在突发性耳聋中的疗效观察[J].中华耳科学杂志,2016,14(2):223-228.
[9] 胡美玲,李高彪,李斐.地塞米松联合鼠神经生长因子穴位注射对老年突发性耳聋的临床研究[J].中国医药导刊,2020,22(8):565-569.
[10] 韩宁,文梅,胡丹.神经生长因子联合盐酸氟桂利嗪对突发性耳聋小鼠的治疗效果及作用机制研究[J].临床和实验医学杂志,2021,20(12):1233-1237.
[11] YUE Y H . Comparison on therapeutic effect of different methods in the treatment of sudden deafness[J].Clin Med,2017,37(12):38-39.
[12] 景阳, 张文, 王宇娟,等. 鼠神经生长因子不同给药方式治疗突发性耳聋的效果比较[J].中国医药导报, 2016, 13(15):127-130.
[13] 王丽芳. 鼠神经生长因子联合地塞米松乳突骨膜下注射治疗突发性耳聋效果评价[J].广西医学,2017,39(1):61-64.
[14] TAI G F . Effect of nerve growth factor on hemorheology in older patients with sudden deafness via two different injection approaches[J].Int J Geriatr,2019,40(1):32-33. |
|
|
|
2024, Vol. 41 
