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| Changes in Serum Levels of sTREM-1,sCD14,and LBP in Elderly Patients with Liver Cirrhosis and Bacterial Peritonitis and their Impact on Patient Prognosis |
| WANG Ping, TIAN Pengfei, ZHOU Ming |
| The Xinxiang Public Health Medical Treatment Center,Henan Xinxiang 453000 |
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Abstract 【Objective】To investigate the changes in sTREM-1,sCD14,and lipopolysaccharide binding protein (LBP) in elderly patients with liver cirrhosis complicated with bacterial peritonitis (SBP).【Methods】A total of 108 elderly patients with liver cirrhosis and SBP admitted to our center and Xinxiang Central Hospital from August 2020 to March 2022 were selected as the observation group,while 108 elderly patients with liver cirrhosis without SBP were selected as the control group. According to the prognosis after 9-12 days of treatment,patients in the observation group were divided into a poor prognosis group (n=38) and a good prognosis group (n=70). The serum levels of sTREM-1,sCD14,and LBP were compared among different groups of patients before treatment,and logistic regression analysis was used to analyze the risk factors of elderly cirrhosis with SBP.【Results】Before treatment,the serum levels of sTREM-1,sCD14,and LBP in the observation group were higher than those in the control group,with statistically significant differences (P<0.05). Logistic regression analysis showed that serum sTREM-1>55.49 μg/mL,sCD14>24.94 mg/L,and LBP >90.79 μg/L before treatment were risk factors for elderly cirrhosis with SBP (P<0.05). After treatment,the serum levels of sTREM-1,sCD14,and LBP in the group with good prognosis were lower than before treatment (P<0.05),while those in the group with poor prognosis were higher than those in the group with good prognosis (P<0.05). The risk of poor prognosis in patients with high levels of serum sTREM-1,sCD14,and LBP in patients with cirrhosis and SBP was 2.116 times,2.992 times,and 2.088 times higher than that in patients with low levels (P<0.05).【Conclusion】Abnormal elevation of serum levels of sTREM-1,sCD14,and LBP can induce cirrhosis with SBP. Detecting their expression levels can provide a reference for clinical prediction of prognosis in patients with cirrhosis with SBP.
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Received: 26 September 2022
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2023, Vol. 40 
