输尿管结石梗阻所致的急性肾功能损伤患者血清KIM-1、PCT、cys C水平变化及意义

doi:10.3969/j.issn.1671-7171.2023.09.009

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1230 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To investigate the changes and significance of Kidney Injury Molecule-1 (KIM-1),Procalcitonin (PCT),and Cystatin C (cys C) levels in the serum of patients with Acute Kidney Injury (AKI) caused by ureteral stone obstruction.【Methods】Ninety patients with ureteral stone obstruction admitted to our hospital were included in the study. Patients were divided into the AKI group (15 cases) and the non-AKI group (75 cases) based on whether AKI occurred during hospitalization. The differences in clinical data and levels of KIM-1,PCT,and cys C were compared between the two groups. Univariate and multivariate logistic regression analyses were used to evaluate the independent risk factors influencing the early occurrence of AKI in patients with ureteral stone obstruction. Receiver operating characteristic (ROC) curves were drawn to evaluate the predictive value of related indicators for the early occurrence of AKI in these patients.【Results】The levels of KIM-1,PCT,and cys C were higher in the AKI group than in the non-AKI group (P<0.05). The differences of clinical data between the two groups were not statistically significant (P>0.05). Multivariate logistic regression analysis showed that KIM-1,PCT,and cys C were independent risk factors affecting the early occurrence of AKI in patients with ureteral stone obstruction (P<0.05). ROC curves showed that KIM-1,PCT,and cys C all had certain predictive efficacy for the early occurrence of AKI in patients with ureteral stone obstruction,with areas under the curve (AUC) of 0.806,0.829,and 0.754,respectively. The combined prediction of the three indicators for the early occurrence of AKI in patients with ureteral stone obstruction had an AUC of 0.927.【Conclusion】The expressions of KIM-1,PCT,and cys C in the serum of patients with AKI caused by ureteral stone obstruction are significantly elevated. They are independent risk factors influencing the early occurrence of AKI,and the combined detection of these three indicators can be used as a screening index for the early occurrence of AKI.

Key words： Ureteral Calculi/CO Acute Kidney Injury/CO Procalcitonin/BL Chalones/BL

Received: 22 November 2022

PACS:

R693.4

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LI Qingying
	REN Mengnan

Cite this article:

LI Qingying,REN Mengnan. Serum Levels and Significance of KIM-1,PCT and cys C in Patients with Acute Kidney Injury Caused by Ureteral Stone Obstruction[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(9): 1311-1314.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2023.09.009 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2023/V40/I9/1311

[1] 齐伟,席俊华,杨晓亮,等. 输尿管壁面积对嵌顿性输尿管结石的预测价值[J].中华医学杂志,2021,101(44):3637-3642.
[2] QIAN S,XIA W,WU Y,et al. Urinary kidney injury molecule-1: a novel biomarker to monitor renal function in patients with unilateral ureteral obstruction[J].Int Urol Nephrol,2020,52(11):2065-2072.
[3] 孟娟,蔡宏瑜,张旭辉,等. 输尿管结石患者术后尿源性脓毒症的影响因素及外周血NLR、PLR、PCT的诊断价值[J].中华医院感染学杂志,2021,31(20):3082-3085.
[4] WEN Y,PARIKH C R. Current concepts and advances in biomarkers of acute kidney injury[J].Crit Rev Clin Lab Sci,2021,58(5):354-368.
[5] FU G,ZHAN H C,LI H L,et al. Association between procalcitonin and acute kidney injury in patients with bacterial septic shock[J].Blood Purif,2021,50(6):790-799.
[6] HIDAYATI E L,UTAMI M D,ROHSISWATMO R,et al. Cystatin C compared to serum creatinine as a marker of acute kidney injury in critically ill neonates[J].Pediatr Nephrol,2021,36(1):181-186.
[7] SAHLÉN K,DAHLMAN P,BREKKAN E,et al. Predictive value of secondary signs of obstruction in follow-up computed tomography of ureteral stones: a study with dynamic computed tomography[J].Scand J Urol,2018,52(1):59-64.
[8] QIAN S,HUANG Y,WANG N,et al. Urinary neutrophil gelatinase-associated lipocalin as a biomarker to monitor renal function in patients with obstructive ureteral calculi[J].World J Urol,2019,37(6):1197-1204.
[9] SHEN K,QU W,ZHAO G K,et al. Kinetic changes in serum procalcitonin predict persistent acute kidney injury in critical patients[J].Nephrology (Carlton),2021,26(11):872-878.
[10] SONG J,YU J,PRAYOGO G W,et al. Understanding kidney injury molecule 1: a novel immune factor in kidney pathophysiology[J].Am J Transl Res,2019,11(3):1219-1229.
[11] HOSTE E,BIHORAC A,AL-KHAFAJI A,et al. Identification and validation of biomarkers of persistent acute kidney injury: the RUBY study[J].Intens Care Med,2020,46(5):943-953.
[12] 朱道谋,钟丽花,陈彩华. 血清和尿NGAL、KIM-1、cys C对晚发型败血症新生儿急性肾损伤的早期预警价值[J].东南大学学报(医学版),2021,40(2):176-182.
[13] KAN W C,HUANG Y T,WU V C,et al. Predictive ability of procalcitonin for acute kidney injury: a narrative review focusing on the interference of infection[J].Int J Mol Sci,2021,22(13):6903-6927.
[14] 董照刚,郑喜胜,贾明雅,等. 尿NAG、血PCT及SOFA评分对脓毒症患者急性肾损伤的预测价值[J].中华医院感染学杂志,2020,30(23):3534-3538.
[15] LI R,WANG X,ZHAO X,et al. Cystatin C level is associated with the recovery of renal function in cancer patients after onset of acute kidney injury[J].Ann Palliat Med,2021,10(2):2158-2166.
[16] 姚梁,张培珠,钟金成. 血液及尿液中cys C、KIM-1、NGAL水平在肝硬化继发急性肾功能损伤患者中的诊断价值[J].中国急救复苏与灾害医学杂志,2021,16(1):68-71.