Changes of Serum Pannexin1 Levels before and after Recanalization of Acute Posterior Circulation Ischemic Cerebral Infarction and its Relationship with Clinical Features
Abstract 【Objective】To investigate the level changes of serum Pannexin1 and its relationship with clinical characteristics in patients with acute post-circulatory ischemic stroke before and after vascular recanalization. 【Methods】A total of 82 patients with acute post-circulatory ischemic stroke who underwent vascular recanalization were selected as the study subjects. Serum Pannexin1 levels before and after vascular recanalization were compared, and the correlation of serum Pannexin1 levels with stroke volume and NIHSS score was analyzed. The predictive value of serum Pannexin1 level for patient prognosis was also evaluated. 【Results】Serum Pannexin1 level was lower after vascular recanalization compared to before recanalization (P<0.05). Mild neurological deficit group had significantly lower serum Pannexin1 level than the severe neurological deficit group before and after recanalization (P<0.05). The mild stroke group had lower serum Pannexin1 level than the severe stroke group (P<0.05). The good prognosis group had lower serum Pannexin1 level than the poor prognosis group (P<0.05). The serum Pannexin1 levels in all groups after vascular recanalization were lower than those before recanalization (all P<0.05). Serum Pannexin1 level was positively correlated with stroke volume and NIHSS score (rs=0.649, 0.614, P<0.05). ROC analysis showed that the area under the curve (AUC) of serum Pannexin1 level for predicting patient prognosis was 0.778. 【Conclusion】Serum Pannexin1 level is elevated in patients with acute post-circulatory ischemic stroke compared to healthy volunteers, and the level of Pannexin1 is positively correlated with stroke volume and NIHSS score, which can provide certain reference value for the clinical prognosis of patients with acute posterior circulation ischemic cerebral infarction.
LIANG Liu-ming,GAO Yu-wei,DU Feng-rong, et al. Changes of Serum Pannexin1 Levels before and after Recanalization of Acute Posterior Circulation Ischemic Cerebral Infarction and its Relationship with Clinical Features[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(7): 1066-1069.
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