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| Expression and Clinical Significance of Adipsin and A-FABP in Serum of Pregnant Diabetes Patients with Insulin Resistance |
| LIAN Rong-li, ZHANG Ren-ping |
| Department of Obstetrics and Gynecology,Ankang Maternal and Child Health Hospital,Ankang Shaanxi 725000 |
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Abstract 【Objective】To investigate the expression and clinical significance of lipase (adipsin) and adipocyte fatty acid binding protein (A-FABP) in the serum of patients with insulin resistance in gestational diabetes (GDM).【Method】A total of 100 GDM patients admitted to Ankang Maternal and Child Health Hospital from June 2019 to June 2022 were selected as the observation group, while 100 healthy pregnant women with normal prenatal examination in the same period were selected as the control group. The levels of triglyceride (TG), total cholesterol (TC), High-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting blood glucose (FPG), fasting insulin (FINS), glycosylated hemoglobin (HbA1c), homeostasis model insulin resistance index (HOMA-IR), adipsin, and A-FABP were compared between the two groups of pregnant women. The Spearman correlation coefficient model was used to analyze the relationship among the indexes of glycolipid metabolism, adipsin, A-FABP and HOMA-IR. The correlation between A-FABP and HOMA-IR was analyzed using unconditional logistic stepwise regression to determine the influencing factors of insulin resistance in GDM patients.【Result】The TG,FPG, HbAlc, FINS, HOMA-IR,adiposin and A-FABP of the observation group were significantly higher than those of the control group (P<0.05). However, there were no statistically significant differences in TC, HDL-C, and LDL-C between the two groups (P>0.05). The correlation analysis showed that a positive correlation with HOMA-IR with levels of FPG, HbAlc, FINS, TG, adiposin, and A-FABP showed(P<0.05). The results of multivariate logistic regression analysis showed that FPG, HbAlc, FINS, TG, adiposin, and A-FABP were the influencing factors for insulin resistance in GDM patients (P<0.05).【Conclusion 】Adipsin and A-FABP are significantly correlated with GDM insulin resistance and they are important indicators for predicting GDM insulin resistance.
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Received: 17 August 2022
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2023, Vol. 40 
