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| Effect of Shenmai Injection on Inflammatory Factors and Renal Function of Septic Acute Kidney Injury |
| SUN Liang, XU Lin, WANG Cai-xia, et al |
| Shandong Provincial Third Hospital,Jinan Shandong 250031 |
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Abstract 【Objective】To investigate the protective effects of Shenmai injection on inflammatory factors and renal function in patients with septic acute kidney injury (AKI). 【Methods】A total of 120 patients with septic AKI were randomly divided into the control group (n=60) and the observation group (n=60). The control group was given routine treatment. While the observation group was treated with shenmai injection on the basis of control group. Both groupswere treated continuously for 7 days. Acute physiology and chronic health evaluation system Ⅱ (APACHEⅡ), serum creatinine (Scr), cystatin C (cys C), heparin binding protein (HBP), tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) levels were compared between two groups before treatment and on 3 d and 7 d after treatment. The duration of mechanical vasoactive drug(noradrenaline)and ventilation was compared between the two groups as well. 【Results】 Before treatment, there were no significant differences in the levels of Scr, cys C, HBP, TNF-α, IL-6 and APACHEⅡ scores between two groups (P<0.05). On day 3 and day 7 after treatment, all the above indexes decreased compared to those before treatment; And on day 7, the indexes decreased more significantly in the observation group than those in the control group (P<0.05). The days of ventilator and vasoactive drug used in the observation group were significantly lower than those in the control group (P<0.05). 【Conclusion】 Shenmai injection may play a protective role in patients with septic AKI by regulating inflammatory mediators.
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Received: 07 July 2022
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2023, Vol. 40 
