Brighton PEWS在重型手足口病并发神经功能损害患儿中的应用价值

doi:10.3969/j.issn.1671-7171.2023.06.033

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1139 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】 To explore the application value of Brighton Pediatric Early Warning Score for Children (Brighton PEWS) in children with severe hand-foot-and-mouth disease complicated with neurological impairment. 【Methods】 A retrospective analysis was conducted on the clinical data of 98 children with severe hand-foot-and-mouth disease complicated with neurological impairment admitted to our hospital from June 2018 to May 2020. They were divided into a control group (with routine intervention) and an observation group (Brighton PEWS application in addition to routine intervention) based on different intervention methods,with 49 cases in each group. The levels of neutrophils,serum Creatine kinase (CK),specific neuron Enolase (NSE),and Creatine kinase Isozyme (CK-MB) were compared before and after the intervention in the two groups. And the antipyretic time,herpes regression time,aphthous stomatitis healing time,and the duration of nerve damage were compared between the two groups. The incidence of pulmonary edema,severe encephalitis and circulatory failure were recorded. 【Results】 The antipyretic time,herpes regression time,aphthous stomatitis healing time and nerve damage duration in the observation group were shorter than those in the control group (P<0.05). After intervention,the levels of neutrophils,CK,NSE,and CK-MB in both groups were lower than those before intervention. And these parameter's levels of the observation group was lower than those of the control group with a statistically significant difference (P<0.05). The incidence of complications in the observation group was 4.08% (2/49),which was lower than the control group's 14.29%(7/49) with a statistically significant difference (χ²=4.009,P<0.05). 【Conclusion】 Brighton PEWS intervention on the basis of routine intervention can effectively shorten the disappearance time of clinical symptoms,effectively reduce the damage of myocardial cells and brain cells,and reduce the incidence of complications in children with severe hand-foot-and-mouth disease complicated with neurological damage.

Key words： Hand, Foot and Mouth Disease Neurologic Manifestations Child

Received: 04 March 2022

PACS:

R725.125

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LI Juan
	HUANG Xiao-feng

Cite this article:

LI Juan,HUANG Xiao-feng. Application of Brighton PEWS in Children with Severe Hand-Foot-and-Mouth Disease Complicated with Neurological Impairment[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(6): 916-919.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2023.06.033 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2023/V40/I6/916

[1] 奚智勇,张申,陈旭.光血清降钙素原和神经元特异性烯化醇酶在早期诊断重症手足口病中的价值[J].医学临床研究,2019,36(7):1428-1430.
[2] 吉连福,杨恩辉,单鸣凤,等.EV71型病毒疫苗接种后住院患儿手足口病流行病学特征及病原学变化[J].中国感染控制杂志,2020,19(6):546-552.
[3] 吴文静.儿科早期预警评分及常见血常规、炎症标志物对危重症手足口病患儿早期诊断的价值[J].标记免疫分析与临床,2021,28(3):472-475.
[4] 全锦花,杨鲁,张新超.血清presepsin(sCD14-ST)联合NEWS评分评估脓毒症患者预后的价值[J].中华急诊医学杂志,2017,26(8):948-952.
[5] 《手足口病诊疗指南(2018版)》编写专家委员会. 手足口病诊疗指南(2018年版)[J].中华传染病杂志,2018,35(5):257-263.
[6] ZHANG K,LV D,DENG Y,et al. STAPLAg a convenient early warning score for use in infected patients in the intensive care unit[J].Medicine(Baltimore),2020,99(22):e20274.
[7] PAN Q,LIU F,ZHANG J,et al. Regional-level risk factors for severe hand-foot-and-mouth disease:an ecological study from mainland China[J].Environ Health Prev Med,2021,26(1):4-9.
[8] 刘坤鹏,罗芳,门光国,等.手足口病重症患儿神经系统损害影响因素研究[J].中国预防医学杂志,2020,21(9):33-35.
[9] 王玉红.重症早期预警及并发症护理在手足口病患儿中的应用[J].山西医药杂志,2019,48(8):999-1001.
[10] 李侗曾,梁连春.手足口病危重症预警评估方法研究进展[J].中国全科医学,2019,22(30):3774-3778.
[11] 罗爱华.血缺氧性脑病新生儿血清缺氧诱导因子-1α、神经元特异性烯醇化酶、细胞间黏附分子-1水平表达及意义[J].中国临床医生杂志,2020,48(10):1249-1251.
[12] 郝东侠,王彦宏,刘丽娜.D-二聚体、纤维蛋白原、心肌酶谱在糖尿病酮症酸中毒感染患者中的表达及其临床意义[J].医学临床研究,2019,36(5):1005-1007.