Abstract 【Objective】 To explore the influencing factors of severe mitral regurgitation (MR) in patients with atrial fibrillation. 【Methods】 A retrospective analysis was conducted on the clinical data of 98 patients with atrial fibrillation complicated with MR admitted to the cardiology department of our hospital from August 2018 to March 2020. They were divided into severe MR group (n=19),moderate MR group (n=46),and mild MR group (n=33) based on the severity of MR. We compared the differences in cardiac ultrasound indicators and clinical data among three groups of patients,and used multivariate logistic regression analysis to investigate the correlation between related indicators and the occurrence of severe MR in patients with atrial fibrillation. The clinical value of the occurrence of severe MR in patients with atrial fibrillation was evaluated using receiver operating characteristic curve (ROC) analysis of related indicators.【Results】 The duration of atrial fibrillation and B-type brain natriuretic peptide (BNP) levels in the severe MR group were significantly higher than those in the moderate and mild MR groups,with statistically significant differences (P<0.05). The left atrial diameter (LAD),mitral valve velocity (MV) and right atrial volume (RAV) in the severe MR group were significantly higher than those in the moderate MR group and the mild MR group,and the left ventricular Ejection fraction (LVEF) was significantly lower than those in the moderate MR group and the mild MR group (P<0.05). Multivariate logistic regression analysis showed that LAD,duration of atrial fibrillation,and BNP were the influencing factors for the occurrence of severe MR in patients with atrial fibrillation (P<0.05). The Receiver operating characteristic analysis showed that the area under the curve (AUC) of LAD in evaluating severe MR in patients with atrial fibrillation was significantly higher than the duration and BNP of atrial fibrillation (P<0.05),and the duration and BNP of atrial fibrillation were equivalent (P>0.05). 【Conclusion】 LAD,BNP,and duration of atrial fibrillation are influencing factors for the occurrence of severe MR in AF patients,and are also potential indicators for identifying severe MR.
DING Xiao-tong,LIU Yan. Analysis of Influencing Factors for Severe Mitral Regurgitation in Patients with Atrial Fibrillation[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(6): 873-875.
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2023, Vol. 40 
