Abstract 【Objective】 To explore the influencing factors of osteoporosis in newly diagnosed type 2 diabetes patients. 【Methods】 A total of 300 newly diagnosed patients with type 2 diabetes from March 2020 to March 2022 were selected. Bone mineral density (BMD) of lumbar spine (L1-4) was measured by dual energy X-ray absorptiometry. According to the BMD value of patients,they were divided into normal bone mass group (n=59),osteopenia group (n=158),and osteoporosis group (n=83). The influencing factors of osteoporosis in newly diagnosed type 2 diabetes patients were analyzed. 【Results】 Among 300 newly diagnosed type 2 diabetes patients,158 cases had bone mass reduction (52.67%),and 83 cases had osteoporosis (27.67%). The age of osteoporosis group was higher than that of osteopenia group and normal bone mass group,while high-density lipoprotein cholesterol (HDL-C) was lower than that of osteopenia group and normal bone mass group. Logistic regression analysis showed that age was significantly positively correlated with the occurrence of osteopenia and osteoporosis in newly diagnosed type 2 diabetes (P<0.05),and HDL-C was significantly negatively correlated with the occurrence of osteopenia and osteoporosis in newly diagnosed type 2 diabetes (P<0.05). 【Conclusion】 The incidence rate of osteoporosis and osteopenia in newly diagnosed type 2 diabetes patients is significantly increased. Age and HDL-C are the influencing factors of osteoporosis in newly diagnosed type 2 diabetes patients.
[1] VILACA T,SCHINI M,HARNAN S,et al. The risk of hip and non-vertebral fractures in type 1 and type 2 diabetes:A systematic review and meta-analysis update[J].Bone,2020,137:115457.
[2] 中华医学会糖尿病分会.中国2型糖尿病防治指南(2020年版) [J].中华糖尿病杂志,2021,13(4):315-409.
[3] 周婷婷,冯正平.绝经后女性2型糖尿病伴骨质疏松患者骨密度与骨代谢指标的相关性分析[J].中国骨质疏松杂志,2019,25(1):29-32.
[4] AMERICAN DIABETES ASSOCIATION. 2. Classiffication and Diabetes of Diabetes:standards of medical care in diabetes-2020[J].Diabetes Care,2020,43(Suppl):S14-S31.
[5] 中国老年学学会骨质疏松委员会,骨质疏松诊断标准学科组. 中国人骨质疏松症建议诊断标准[J]. 2版.中国骨质疏松杂志,2000,6(1):1-3.
[6] HYGUM K,STARUP-LINDE J,HARSLOF T,et al. Mechanisms in endocrinology:diabetes mellitus,a state of low bone turnover a systematic review and meta-analysis[J].Eur J Endocrinol,2017,176(3):R137-R157.
[7] WANG L,YU W,YIN X,et al. Prevalence of osteoporosis and fracture in China:The China osteoporosis prevalence study[J].JAMA Netw Open,2021(8):e212106.
[8] 李硕,倪向敏,王建,等. 2型糖尿病性骨质疏松发病机制研究进展[J].中国骨质疏松杂志, 2021,27(11):1661-1665.
[9] 中华医学会骨质疏松和骨矿盐疾病分会. 原发性骨质疏松症诊疗指南(2017)[J].中华内分泌代谢杂志,2017,33(10):890-913.
[10] 刘倩,张捷,申睿婷,等. 住院2型糖尿病男性患者骨质疏松相关危险因素分析[J].中国骨质疏松杂志,2021,27 (10):1486-1490.
[11] YAMAGUCHI T,SUGIMOTO T,YANO S,et al. Plasma lipids and osteoporosis in postmenopausal women[J].Endocr J,2002,49(2):211-217.
[12] 吴静,周灵丽,白玉晓,等. 住院新诊断2型糖尿病患者骨密度及影响因素调查[J].中国骨质疏松杂志,2016,22(3):321-325.
2023, Vol. 40 
