甲状腺功能亢进对2型糖尿病患者血清IGF-1及骨代谢指标的影响

doi:10.3969/j.issn.1671-7171.2023.04.018

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Abstract 【Objective】 To investigate the effects of hyperthyroidism on serum insulin-like growth factor-1 (IGF-1) and bone metabolism in patients with type 2 diabetes. 【Methods】 Seventy-seven patients with type 2 diabetes mellitus complicated with hyperthyroidism admitted to the Central Hospital of Tongchuan Mining Administration from February 2017 to February 2022 were enrolled in the observation group,and 70 patients with type 2 diabetes mellitus without hyperthyroidism admitted to Central Hospital of Tongchuan Mining Bureau during the same period were considered as the control group. Blood glucose [fasting blood glucose (FPG),glycosylated hemoglobin (HbA1c)] and thyroid function [free triiodothyronine (FT₃),free thyroxin (FT₄),thyroid stimulating hormone (TSH)] indexes of the two groups were detected and compared. The levels of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-2 (IGF-2) were detected and compared between the two groups. Bone metabolism indexes of the two groups were detected and compared,including bone specific alkaline phosphatase (BAP),n-terminal osteocalcin (N-MID-OT),total type 1 collagen amino terminal prolongating peptide (T-P1NP),β-crosslaps (β-CTX),1,25 dihydroxyvitamin D₃[1,25(OH)₂D₃]. Bone mineral density levels were measured in different parts of patients in the two groups:the 2nd-4th lumbar spine (L_2-4),Ward's triangle,neck of femur,and greater trochanteric area. 【Results】 The levels of FPG,FT₃,BAP,N-MID-OT,T-P1NP,β-CTX and FT₄ in the observation group were significantly higher than those in the control group (P<0.05),while the levels of TSH,TSH,IGF-1,IGF-2 and 1,25(OH)₂D₃ in the observation group was significantly lower than those in the control group (P<0.05). There was no significant difference in HbA1c level between the two groups (P>0.05). The bone mineral densities of L_2-4,Ward's triangle,neck of femur and greater trochanter in the observation group were significantly lower than those in control group (P<0.05). 【Conclusion】 The levels of blood glucose and thyroid in type 2 diabetes patients with hyperthyroidism are higher than those in patients without hyperthyroidism. Patients with T2DM have lower serum IGF-1,abnormal bone metabolism,and lower bone mineral density lower than those in patients without hyperthyroidism. Clinical monitoring of bone metabolism is necessary to prevent the occurrence of osteoporosis.

Key words： Diabetes Mellitus,Type 2 Hyperthyroidism Insulin-Like Growth Factor I/BL Bone and Bones/ME

Received: 25 August 2022

PACS:

R587.1

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	SHI Yan-hong
	LI Hai-ming

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SHI Yan-hong,LI Hai-ming. Effects of Hyperthyroidism on Serum IGF-1 and Bone Metabolism Indexes in Type 2 Diabetes Mellitus[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(4): 547-549.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2023.04.018 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2023/V40/I4/547

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