三七通舒胶囊联合rt-PA静脉溶栓对急性缺血性脑卒中患者IGF-1、MMP-9水平的影响

doi:10.3969/j.issn.1671-7171.2023.04.017

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1141 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】 To explore the effect of Sanqi Tongshu capsule combined with recombinant tissue plasminogen activator (rt-PA) intravenous thrombolysis on the levels of insulin-like growth factor-1 (IGF-1) and matrix metalloproteinase-9 (MMP-9) in patients with acute ischemic stroke (AIS). 【Methods】 A total of 240 patients with AIS admitted to our hospital were randomly divided into two groups,with 120 cases in each group. The control group was treated with rt-PA intravenous thrombolysis,while the observation group was treated with Sanqi Tongshu capsule combined with rt-PA intravenous thrombolysis. The treatment in the two groups lasted for 4 weeks. The curative effect,adverse reactions and the levels of Barthel index (BI),neurological function score (NIHSS),balance function score (BBS),TCM symptom score,IGF-1,MMP-9,calcitonin gene-related peptide (CGRP) of the two groups were compared before and after treatment. 【Results】 After treatment,the serum NIHSS of patients in the observation group was significantly lower than that before treatment in the observation group and after treatment in the control group,and the scores of BBS and BI were significantly higher than those before treatment of the observation group and after treatment in of the control group (P<0.05). The total effective rate of treatment in the observation group was 95.00%,which was significantly higher than 87.50% in the control group (P<0.05). After treatment,the scores of hemiplegia,mouth and eye deviation,and speech impairment in the observation group were lower than those before treatment in the observation group and after treatment in the control group (P<0.05). The levels of serum MMP-9 and CGRP of the observation group after treatment were significantly lower than those of the observation group before treatment and of the control group after treatment,while the level of IGF-1 was significantly higher than that of the observation group before treatment and of the control group after treatment(P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】 Sanqi Tongshu capsule combined with rt-PA intravenous thrombolytic therapy for AIS can increase the clinical efficacy,regulate the serum levels of MMP-9,IGF-1 and CGRP,improve the recovery of nerve function,enhance the ability of daily living and balance,while not increase adverse drug reactions.

Key words： Brain Ischemia Stroke Acute Disease Tissue Plasminogen Activator/PD Sanqi Tongshu Jiaonang/PD

Received: 11 August 2022

PACS:

R743.3

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHAO Shu-ping
	WANG Xue-ling
	WANG Wen-hui

Cite this article:

ZHAO Shu-ping,WANG Xue-ling,WANG Wen-hui. Effect of Sanqi Tongshu Capsule Combined with rt-PA Intravenous Thrombolysis on IGF-1 and MMP-9 Levels in Patients with Acute Ischemic Stroke[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(4): 543-546.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2023.04.017 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2023/V40/I4/543

[1] MENDELSON S J,PRABHAKARAN S. Diagnosis and management of transient ischemic attack and acute ischemic stroke:A review[J].JAMA,2021,325(11):1088-1098.
[2] JOLUGBO P,ARIËNS R A S. Thrombus composition and efficacy of thrombolysis and thrombectomy in acute ischemic stroke[J].Stroke,2021,52(3):1131-1142.
[3] EBINGER M,SIEGERINK B,KUNZ A,et al. Association between dispatch of mobile stroke units and functional outcomes among patients with acute ischemic stroke in berlin published correction appears in[J].JAMA,2021,325(5):454-466.
[4] WANG J H,TIAN L,ZHANG Z C,et al. Scalp-acupuncture for patients with hemiplegic paralysis of acute ischaemic stroke:A randomized controlled clinical trial[J].J Tradit Chin Med,2020,40(5):845-854.
[5] 刘禹,邵海宇,王琦. 三七总皂苷结合针灸干预对急性缺血性脑卒中大鼠血脑屏障的保护作用及对PI3K/Akt信号通路的影响[J].中国中医急症,2020,29(4):649-652.
[6] 中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组. 中国急性缺血性脑卒中诊治指南2018[J].中华神经科杂志,2018,51(9):666-682.
[7] 国家中医药管理局.中医病证诊断疗效标准[S].南京:大学出版社,1994:64.
[8] 符茂东,张雯,李笑笑,等. 急性缺血性脑卒中病人Barthel指数与中医证型的相关性分析[J].中西医结合心脑血管病杂志,2018,16(16):2300-2303.
[9] 谭洪辉,黄之文,杨雀飞. 急性缺血性脑卒中患者T细胞亚群与NIHSS评分相关性研究[J].海南医学,2018,29(12):1690-1692.
[10] 余友金,周小炫,陈雨,等. 针刺夹脊穴配合虚拟平衡游戏对脑卒中患者平衡功能的影响[J].上海针灸杂志,2017,36(7):765-768.
[11] 徐杰文. 阿替普酶静脉溶栓治疗急性缺血性脑卒中32例疗效观察[J].中国药业,2017,26(18):50-52.
[12] 郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国中医药出版社,2002:253-258.
[13] JIANG C T,WU W F,DENG Y H,et al. Modulators of microglia activation and polarization in ischemic stroke (review)[J].Mol Med Rep,2020,21(5):2006-2018.
[14] 姜超,王婷,方邦江,等. 益气活血方治疗栓子阳性急性缺血性脑卒中病人中医证候疗效评价的随机对照试验[J].中西医结合心脑血管病杂志,2020,18(19):3181-3184.
[15] 杨保华,付胜,伏冬梅. 舒血宁注射液联合重组组织型纤溶酶原激活剂静脉溶栓治疗急性缺血性脑卒中疗效及对血清脂蛋白相关磷脂酶A2、同型半胱氨酸、高敏C反应蛋白水平的影响[J].实用医院临床杂志,2020,17(6):79-82.