Abstract 【Objective】 To explore the influencing factors of myasthenia gravis crisis (POMC) after thymectomy in children with myasthenia gravis (MG). 【Methods】 A total of 78 children with MG who underwent thymectomy were admitted to our hospital,of which 28 had POMC (POMC group) and 50 did not(the non POMC group). The influencing factors of POMC after thymectomy in MG patients were analyzed. 【Results】 Univariate analysis showed that the duration of MG in the POMC group and the non POMC group was (34.0 ± 4.8) months and (11.0 ± 1.4) months,respectively,with a statistically significant difference between the two groups (P<0.05); In the POMC group,there were 2 cases (7.1%),21 cases (75.0%),4 cases (14.3%),and 1 case (3.6%) of modified Osserman classification Ⅱa,Ⅱb,Ⅲ,and Ⅳ,respectively. In the non POMC group,there were 15 cases (30.0%),32 cases (64.0%),3 cases (6.0%),and 0 cases,respectively,with statistically significant differences (P<0.05); In the POMC group,18 cases (64.3%) underwent video-assisted thoracoscopic surgery and 10 cases (35.7%) underwent traditional open surgery,respectively. There was a statistically significant difference compared to 45 cases (90.0%) and 5 cases (10.0%) in the non POMC group (P<0.05); There were 13 cases (46.4%) and 0 cases of postoperative pneumonia in the POMC group and the non POMC group,respectively,with a statistically significant difference between the two groups (P<0.05). The statistically significant factors in univariate analysis were used as independent variables,and the occurrence of POMC in MG patients was included as the dependent variable in logistic regression analysis. The results suggest that the course of MG and postoperative pneumonia are independent risk factors for POMC in MG patients (P<0.05),while the surgical method (video-assisted thoracoscopic surgery) is a protective factor (P<0.05). 【Conclusion】 The occurrence of POMC in pediatric MG patients after thymectomy is closely related to the course of preoperative MG and postoperative pneumonia; Compared to traditional open surgery,video-assisted thoracoscopic surgery can significantly avoid the occurrence of POMC and is worthy of clinical promotion.
ZHANG Si-si,WANG Jun,ZHANG Kun. Factors Affecting Myasthenia Gravis Crisis after Thymectomy in Children with Myasthenia Gravis[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(4): 508-510.
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2023, Vol. 40 
