Abstract 【Objective】 To investigate the correlation between ciRs-126 and acute kidney injury(AKI) in patients with sepsis. 【Methods】 Eighty patients with sepsis admitted to our hospital were divided into two groups according to the degree of renal injury:AKI group (30 cases) and non-AKI group (50 cases). General information,disease score and ciRs-126 levels of the two groups were compared. 【Results】 There were no differences in age,sex,body mass index (BMI),underlying complications,smoking history and drinking history between the two groups (P>0.05). There were no differences in tumor necrosis factor-α (TNF-α),hypersensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6) levels between the two groups (P>0.05). Serum creatinine (Scr) and serum urea nitrogen (BUN) levels in the AKI group were higher than that in the non-AKI group,while the glomerular filtration rate (eGFR) level in the AKI group was lower than that in non-AKI group (P<0.05). The sequential organ failure score (SOFA) and acute physiological and chronic health score (APACHE Ⅱ) in the group with AKI were higher than those in the group without AKI (P<0.05). The level of ciRs-126 in the group with AKI was higher than that in the group without AKI (P<0.05). ROC analysis showed that Scr,eGFR,SOFA,APACHE Ⅱ and ciRs-126 could be used to predict occurrence of AKI after sepsis,and the areas under the curve were 0.725,0.800,0.687,0.751 and 0.785,respectively,(P<0.05). Multivariate Logistic regression analysis confirmed that Scr≥156.70 μmol/L,eGFR≤84.58 mL/min,SOFA≥13.24 scores,APACHE Ⅱ≥29.26 scores,ciRs-126≥3.76 were risk factors for AKI after sepsis(P<0.05).【Conclusion】 The increase of ciRs-126 level can predict the occurrence of AKI in patients with sepsis. It is necessary to strengthen the monitoring of this index.
QI Heng,GAO Jing. Relationship between ciRs-126 and Acute Kidney Injury in Patients with Sepsis[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(4): 504-507.
[1] 张萌,方悦,赵正.血必净注射液联合持续性肾脏替代治疗脓毒症合并急性肾损伤患者的疗效[J].中国医师杂志,2019,21(8):1239-1240. [2] JI R,CHEN W,WANG Y,et al. The warburg effect promotes mitochondrial injury regulated by uncoupling protein-2 in septic acute kidney injury[J].Shock,2021,55(5):640-648. [3] 中国医师协会急诊医师分会中国研究型医院学会休克与脓毒症专业委员会.中国脓毒症/脓毒性休克急诊治疗指南(2018)[J].感染、炎症、修复,2019,20(1):3-22. [4] 李晓刚,张宁,江宇星,等.中性粒细胞与淋巴细胞比值联合序贯器官功能衰竭评分对老年脓毒症患者预后的预测作用[J].中华老年多器官疾病杂志,2021,20(2):98-101. [5] 谷阁,王润之,张梦辉,等.血清淀粉样蛋白A联合APACHE Ⅱ评分对急性胰腺炎预后的预测价值[J].中国急救复苏与灾害医学杂志,2022,17(12):1626-1629. [6] JIN B,CAO D,YANG N,et al. Early high-dose continuous veno-venous hemofiltration alleviates the alterations of CD4+ T lymphocyte subsets in septic patients combined with acute kidney injury[J].Artif Organs,2022,46(7):1415-1424. [7] 王英丽,孙明忠,季禹乔,等.脓毒症相关急性肾损伤患者血清中性粒细胞明胶酶相关脂质运载蛋白与肾功能关系的研究[J].中国急救复苏与灾害医学杂志,2022,17(5):604-606. [8] JURY D,SHAW A D. Utility of bedside ultrasound derived hepatic and renal parenchymal flow patterns to guide management of acute kidney injury[J].Curr Opin Crit Care,2021,27(6):587-592. [9] 李佳,袁野,罗娟娟,等.联合肾动脉阻力指数和β2微球蛋白及降钙素原水平构建脓毒症合并急性肾损伤患者预后模型的验证评价[J].临床急诊杂志,2022,23(10):727-732. [10] 单朝阳,陈强,林俊伟.血清胱抑素C水平对脓毒症合并急性肾损伤患者连续性肾脏替代治疗启动时机的预测价值[J].河南医学研究,2022,31(18):3355-3357. [11] DEEP A,SAGAR H,GOONASEKERA C,et al. Evolution of acute kidney injury and its association with systemic hemodynamics in children with fluid-refractory septic shock[J].Crit Care Med,2018,46(7):677-683. [12] 黄辉权.PCT、SCr、BUN与脓毒症合并急性肾损伤患者的关系[J].医学临床研究,2020,37(1):111-113.
2023, Vol. 40 
