|
|
|
| Effects of Qingre Xingnao Decoction Combined with Edaravone on the Neural Function of the Penumbra in Patients with Ischemic Stroke |
| SHU Yu-gao |
| Hunan Provincial People's Hospital,The First Affiliated Hospital of Hunan Normal University,Changsha Hunan 410005 |
|
|
|
|
Abstract 【Objective】 To investigate the effect of Qingre Xingnao Decoction combined with edaravone on the neural function of the penumbra in patients with ischemic stroke. 【Methods】 From January 2019 to February 2021,40 patients with ischemic stroke admitted to the neurosurgery department of our hospital were randomly divided into observation group and control group,with 20 patients in each group. The control group was treated with edaravone on the basis of routine treatment,while the observation group was treated with Qingre Xingnao Decoction on the basis of the control group. Comparison of ischemic penumbra perfusion parameters between two groups of patients before and after treatment[Cer ebral blood flow (CBF),cerebral blood volume (CBV),mean transit time (MTT) and the time of peak (TTP) of the contrast agent],inflammatory factors [interleukin-3 (IL-3),interleukin-5 (IL-5),interleukin-8 (IL-8)] and adverse reactions and neurological function were compared between the two groups. 【Results】 On the 7 and 14 days after treatment,CBF,MTT,and TTP in the two groups were lower than those before treatment,and the observation group was lower than the control group. The CBV level in the two groups was higher than that before treatment,and the observation group was higher than the control group,with significant differences (P<0.05); The serum levels of IL-3,IL-5,and IL-8 in the two groups were lower than those before treatment,and the observation group was lower than the control group,with significant differences (P<0.05); The CSS scores of patients in both groups were lower than before treatment,and the observation group was lower than the control group,with significant differences (P<0.05). The incidence of adverse reactions in the observation group was 20.0% (4/20),while that in the control group was 15.0% (3/20). There was no statistically significant difference between the two groups (P=0.677). 【Conclusion】 Qingre Xingnao Decoction combined with edaravone can improve the neural function of the penumbra and reduce the level of inflammatory factors in patients with ischemic stroke,which is safe and effective,and is worthy of clinical promotion.
|
|
Received: 19 May 2022
|
|
|
|
|
|
[1] 付志勇,王正则,孙晓红.磁共振血管成像-扩散加权成像不匹配预测基底动脉闭塞型急性后循环脑梗死缺血半暗带的价值[J].中国脑血管病杂志,2019,16(11):587-592.
[2] 徐小雨,姚蓓蓓,朱清,等.炎性标志物与缺血性卒中的研究进展[J].实用老年医学,2020,34(2):181-185.
[3] 高满满,颜丙春.缺血性脑卒中后认知功能障碍生物学标志物及预测因子研究进展[J].中国医药导报,2020,17(3):26-29.
[4] 于晓云.丁苯酞对缺血性脑卒中缺血半暗带细胞因子及神经功能的影响[J].中国实用神经疾病杂志,2019,22(1):51-55.
[5] 韩春辉.依达拉奉对大鼠脑缺血再灌注损伤的保护作用研究[J].中外医疗,2015,15(6):114-115.
[6] 王永炎,张伯礼. 中医脑病学[M].北京:人民卫生出版社,2007.
[7] 张茹,朱政锜,朱丽,等.基于ADC图的影像组学模型在判断急性缺血性脑卒中缺血半暗带的价值[J].中华放射学杂志,2021,55(4):383-389.
[8] 杨迪,周加华,白万胜. CTP与DWI检查在急性脑梗死缺血半暗带中的应用价值[J].医学临床研究,2021,38(12):1846-1849.
[9] 孙晓莉,武岳,秦敏,等,依达拉奉治疗急性脑出血的疗效及其对脑钠肽和肽素水平的影响[J].疑难病杂志,2021,15(2):1215-1218.
[10] 贾楠婕,冯俊杰.醒脑静联合依达拉奉治疗脑出血对患者VEGF、BNP及和肽素水平的影响[J].医学临床研究,2021,38(6):890-892.
[11] POZZI-MUCELLI R A,FURLANIS G,CARUSO P,et al. A novel fast CT perfusion core-penumbra mismatch score:correlation with stroke outcome[J].Neurologist,2021,26(2):41-46.
[12] 王凯,张学琴,杨珍珍,等.神经保护剂改善急性缺血性脑卒中神经功能的网状Meta分析[J].中南药学,2020,18(4):685-693.
[13] 李明芬.依达拉奉对脑缺血再灌注损伤的保护机制[J].海峡药学,2013,25(11):117-120. |
|
|
|
2023, Vol. 40 
