脑胶质瘤患者围术期抑郁与焦虑状况及其影响因素

doi:10.3969/j.issn.1671-7171.2023.02.022

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Abstract 【Objective】To explore the status of depression and anxiety in patients with glioma during perioperative period and its influencing factors. 【Methods】 The clinical data of 104 patients with gliomas who received elective surgery from January 2016 to January 2018 were retrospectively analyzed,and the preoperative and postoperative related indicators were recorded. The preoperative indicators included tumor site,preoperative chemotherapy,level of serum vascular endothelial growth factor (VEGF) 3 days before surgery and the proposed surgical form. The postoperative indicators included pathological grade of gliomas,fatigue degree,and serum VEGF level the next day after surgery,Univariate analysis and multivariate regression were used to analyze the influencing factors of anxiety and depression in patients with glioma during perioperative period.【Results】 Single factor analysis showed that the scores of anxiety and depression of patients with different age,sex,course of disease,marital status,educational level,recurrence,tumor site,preoperative and postoperative serum VEGF level,surgical method,pathological grade of glioma,and postoperative fatigue were lower than those before surgery,and the differences were statistically significant (P<0.05). Multivariate regression analysis showed that the influencing factors of preoperative anxiety in patients with glioma were marriage and high grade of glioma(P<0.05). The influencing factors of preoperative depression were serum VEGF level ≥ 56 pg/mL and frontotemporal lobe (P<0.05). The influencing factors of postoperative anxiety were marriage and high grade of glioma(P<0.05). The influential factors of postoperative depression were women and high grade of glioma (P<0.05). 【Conclusion】 The influencing factors of anxiety and depression in patients with brain glioma during perioperative period are marriage,high grade of glioma,preoperative serum VEGF level ≥ 56 pg/mL,frontotemporal lobe and female. Clinical medical staff should pay attention to the patients with the above influencing factors.

Key words： Glioma/SU Brain Neoplasms/SU Depression Anxiety

Received: 22 December 2021

PACS:

R739.41

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	YAN Mei-lin
	ZHAO Ru

Cite this article:

YAN Mei-lin,ZHAO Ru. Perioperative Depression and Anxiety in Patients with Glioma and their Influencing Factors[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(2): 237-240.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2023.02.022 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2023/V40/I2/237

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