|
|
|
| Relationship of HBsAg/HBV DNA Ratio with TGF-β1 and Tim-3 Levels in Patients with Hepatitis B |
| YAO Bo-fang, GAO Fang-fang |
| Department of Laboratory,the Fourth People's Hospital of Shaanxi Province,Xi'an Shaanxi 710043 |
|
|
|
|
Abstract 【Objective】To investigate the relationship of ratio of hepatitis B surface antigen (HBsAg)/hepatitis B virus (HBV) DNA with transforming growth factor-β1(TGF-β1) and T lymphocyte immunoglobulin mucin 3 (Tim-3) levels in patients with hepatitis B.【Methods】Seventy patients with hepatitis B admitted to our hospitals were divided into the mild HBV group (22 cases),the moderate HBV group (30 cases) and the severe HBV group (18 cases) according to the severity of the disease.Another 30 healthy people who were examined at the same time were selected as the control group.The clinical blood biochemical data of all subjects,liver function indexes,TGF-β1,Tim-3 level and the ratio of HBsAg/HBV DNA were analyzed by Pearson correlation.【Results】The levels of serum alanine aminotransferase (ALT),aspartate aminotransferase (AST),total bilirubin (TBIL) and platelet count (PLT) in patients with HBV of different severity and the control groups were in order of the control group<the mild HBV group the moderate HBV group the severe HBV group.The differences among the groups were significant (P<0.05).The comparison of HBsAg/HBV DNA ratios in each group showed the order of the mild HBV group>the moderate HBV group>the severe HBV group (P<0.05).The levels of TGF -β1 and Tim-3 in the control group were lower than those in all HBV groups (the mild HBV group the moderate HBV group the severe HBV group) (all P<0.05).HBsAg/HBV DNA ratio-was significantly negatively correlated to levels of TGF-β1 and Tim-3 in Patients with Hepatitis B (P<0.05).【Conclusion】The ratio of HBsAg/HBV DNA is negatively related to levels of both TGF-β1 and Tim-3 in patients with hepatitis B.
|
|
Received: 19 April 2022
|
|
|
|
|
|
[1] 王珍子,王铁山,苏建荣.慢性乙肝患者乙型肝炎病毒大蛋白(HBV-LP)与HBV复制相关性研究[J].中华微生物学和免疫学杂志,2020,40(2):543-545.
[2] HAO R,XIANG K,SHI Y,et al.Naturally occurring mutations within hbv surface promoter Ⅱ sequences affect transcription activity,HBsAg and HBV DNA levels in HBeAg-positive chronic hepatitis B patients[J].Viruses,2019,11(1):78-79.
[3] HU H H,LIU J,CHANG C L,et al.Level of hepatitis B (HB) core antibody associates with seroclearance of HBV DNA and HB surface antigen in HB e antigen-seronegative patients[J].Clin Gas Hep,2019,17(1):172-181.
[4] 李文庭,肖珲,杨亮,等.HBV激活转化生长因子β1/Nur77信号通路对肝纤维化的促进作用[J].医学研究生学报,2020,33(4):356-362.
[5] GARCIA M,LENS S,PALLETT L J,et al.Viral and immune factors associated with successful treatment withdrawal in HBeAg-negative chronic hepatitis B patients[J].J Hepatol,2021,74(5):1064-1074.
[6] 中华医学会感染病学分会,中华医学会肝病学分会.慢性乙型肝炎防治指南(2019年版)[J].中华传染病杂志,2019,37(12):711-736.
[7] LIU Y,ZHAO M,GONG M,et al.Inhibition of hepatitis B virus replication via HBV DNA cleavage by Cas9 from Staphylococcus aureus[J].Antiviral Res,2018,15(2):58-67.
[8] 李小鹏,李雷,袁松松,等.高灵敏乙型肝炎病毒DNA阴性慢性乙型肝炎患者70例血清乙型肝炎病毒前基因组RNA水平的分析[J].中华传染病杂志,2021,39(9):415-416.
[9] WANG X D,LIU J P,SONG T R,et al.Kidney transplantation from hepatitis B surface antigen (HBsAg)-positive living donors to hbsag-negative recipients:clinical outcomes at a high-volume center in China[J].Clin Infect Dis,2021,72(6):1016-1023.
[10] 申红玉,张宏宇,陈敏,等.乙型肝炎患者不同突变谱的乙肝表面抗原水平变化[J].实用医学杂志,2020,36(3):55-58.
[11] 王莉,赵媛.慢性乙型肝炎患者血清sVAP-1、DNMT1、Tim-3水平与肝功能指标及炎症因子的相关性[J].海南医学,2021,32(24):3158-3161.
[12] CHENG J.Clinical characteristics and correlation analysis of subjects with chronic hepatitis B virus (HBV) infection and sustained low levels of hepatitis B surface antigen (HBsAg)[J].Med Sci Monit,2018,2(4):1826-1835.
[13] 刘宗萍.慢性乙肝患者血清Tim-3、HBsAg、TGF-β1水平表达与病情程度相关性研究[J].现代检验医学杂志,2019,34(6):77-81.
[14] 李鸽,王洁,鲍艳婷,等.慢性乙型肝炎HBsAg及HBsAg/HBV DNA比值与组织病理炎症活动度的相关性[J].中华肝脏病杂志,2015,23(1):40-45. |
|
|
|
2023, Vol. 40 
