Abstract 【Objective】To investigate the efficacy of gonadotropin-releasing hormone agonist(GnRH-a) combined with bipolar radiofrequency endometrial ablation(BREA) in the treatment of patients with perimenopausal abnormal uterine bleeding. 【Methods】From June 2019 to June 2021,86 patients with perimenopausal abnormal uterine bleeding treated in our hospital were selected and randomly divided into the observation group and the control group,with 43 cases in each group. The control group was treated with BREA,while the observation group received GnRH-a combined with BREA treatment. The efficacy rate,as well as changes in the Pictorial Blood Assessment Chart(PBAC) score,uterine volume,endometrial thickness,and levels of sex hormones [estradiol(E2),luteinizing hormone(LH),follicle-stimulating hormone(FSH),progesterone(P)] before and after treatment were compared between the two groups. 【Results】Before treatment,there was no significant difference in PBAC scores between the two groups(P>0.05). Three months,six months,and twelve months after treatment,PBAC scores of both groups showed a downward trend,and the PBAC scores of the observation group were consistently lower than those of the control group(P<0.05). The effective rate of the observation group was higher than that of the control group at three months,six months,and twelve months after treatment(P<0.05). Before treatment,there was no significant difference in the levels of E2,LH,FSH,and P between the two groups(P>0.05). After treatment,the levels of E2,LH,FSH,and P decreased in both groups,with the observation group showing lower levels than the control group(P<0.05). Before treatment,there was no significant difference in uterine volume and endometrial thickness between the two groups(P>0.05). Six months and twelve months after treatment,both uterine volume and endometrial thickness were reduced in both groups,with the observation group having smaller measurements than the control group(P<0.05). 【Conclusion】Pre-treatment with GnRH-a before BREA therapy in patients with perimenopausal abnormal uterine bleeding can improve clinical efficacy,adjust serum sex hormone levels,and reduce PBAC scores,and is of clinical value for widespread promotion.
LEI Xiaojuan,LI Hongyan,GUO Tianbao. Clinical Efficacy of GnRH-a Combined with BREA in the Treatment of Perimenopausal Abnormal Uterine Bleeding[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(11): 1663-1666.
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