GnRH-a联合BREA治疗围绝经期异常子宫出血的临床疗效

doi:10.3969/j.issn.1671-7171.2023.11.014

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Abstract 【Objective】To investigate the efficacy of gonadotropin-releasing hormone agonist(GnRH-a) combined with bipolar radiofrequency endometrial ablation(BREA) in the treatment of patients with perimenopausal abnormal uterine bleeding. 【Methods】From June 2019 to June 2021,86 patients with perimenopausal abnormal uterine bleeding treated in our hospital were selected and randomly divided into the observation group and the control group,with 43 cases in each group. The control group was treated with BREA,while the observation group received GnRH-a combined with BREA treatment. The efficacy rate,as well as changes in the Pictorial Blood Assessment Chart(PBAC) score,uterine volume,endometrial thickness,and levels of sex hormones [estradiol(E₂),luteinizing hormone(LH),follicle-stimulating hormone(FSH),progesterone(P)] before and after treatment were compared between the two groups. 【Results】Before treatment,there was no significant difference in PBAC scores between the two groups(P>0.05). Three months,six months,and twelve months after treatment,PBAC scores of both groups showed a downward trend,and the PBAC scores of the observation group were consistently lower than those of the control group(P<0.05). The effective rate of the observation group was higher than that of the control group at three months,six months,and twelve months after treatment(P<0.05). Before treatment,there was no significant difference in the levels of E₂,LH,FSH,and P between the two groups(P>0.05). After treatment,the levels of E₂,LH,FSH,and P decreased in both groups,with the observation group showing lower levels than the control group(P<0.05). Before treatment,there was no significant difference in uterine volume and endometrial thickness between the two groups(P>0.05). Six months and twelve months after treatment,both uterine volume and endometrial thickness were reduced in both groups,with the observation group having smaller measurements than the control group(P<0.05). 【Conclusion】Pre-treatment with GnRH-a before BREA therapy in patients with perimenopausal abnormal uterine bleeding can improve clinical efficacy,adjust serum sex hormone levels,and reduce PBAC scores,and is of clinical value for widespread promotion.

Key words： Uterine Hemorrhage/TH Perimenopause Gonadotropin-Releasing Hormone/PD Endometrial Ablation Techniques

Received: 16 February 2023

PACS:

R711.52

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	LEI Xiaojuan
	LI Hongyan
	GUO Tianbao

Cite this article:

LEI Xiaojuan,LI Hongyan,GUO Tianbao. Clinical Efficacy of GnRH-a Combined with BREA in the Treatment of Perimenopausal Abnormal Uterine Bleeding[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(11): 1663-1666.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2023.11.014 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2023/V40/I11/1663

[1] CHAPAGAIN S,DANGAL G. Clinical and histopathological presentation of abnormal uterine bleeding in perimenopausal women in tertiary center of nepal[J].J Nepal Health Res Counc,2020,18(2):248-252.
[2] DESTEPHANO C C,ALLYSE M A,DABRH A M M A,et al. Pilot study of women's perspectives when abnormal uterine bleeding occurs during perimenopause[J].Climacteric,2022,25(5):510-515.
[3] 沈育红,刘延,龙雯晴.左炔诺孕酮宫内节育系统联合宫腔镜子宫内膜电切术治疗围绝经期异常子宫出血的临床疗效及安全性评价[J].临床和实验医学杂志,2021,20(2):197-200.
[4] ZHAI Y,ZHANG Z H,WANG W,et al. Meta-analysis of bipolar radiofrequency endometrial ablation versus thermal balloon endometrial ablation for the treatment of heavy menstrual bleeding[J].Int J Gynaecol Obstet,2018,140(1):3-10.
[5] EISELE L,KÖCHLI L,STÄDELE P,et al. Predictors of a successful bipolar radiofrequency endometrial ablation[J].Geburtshilfe Frauenheilkd,2019,79(3):286-292.
[6] 王芝英.诺舒子宫内膜去除系统对功能失调性子宫出血患者疗效及血清性激素水平的影响[J].中国妇幼保健,2018,33(23):5316-5319.
[7] 丁淼,王良岸,李扬志,等.坤泰胶囊改善GnRH-a所致围绝经期症状的前瞻性随机对照研究[J].中国实用妇科与产科杂志,2019,35(4):462-465.
[8] KAUL A R,GUPTA U P,KANT D,et al. Intramyometrial pregnancy presenting as abnormal uterine bleeding in perimenopausal female[J].J Midlife Health,2022,13(1):85-87.
[9] GUAN L L,XUE L L,CHU J P,et al. Effect of Tiaojingzhixue Fang on the expression of sex hormone and endometrial tissue mRNA in perimenopausal patients with abnormal uterine bleeding[J].Cell Mol Biol(Noisy-le-grand),2022,67(5):317-323.
[10] 赖威,陈豫中,张国安.双橘颗粒联合GnRH-a对子宫肌瘤患者子宫动脉血流动力学及性激素水平的影响[J].现代中西医结合杂志,2020,29(20):2262-2265.
[11] 赵梦丹,李君琴,杨佩磊,等.不同促性腺激素释放激素激动剂治疗子宫内膜异位症的应用情况和疗效分析[J].中国现代应用药学,2020,37(5):604-607.
[12] 阎蓓,邸石,代小燕,等.GnRH-a联合腹腔镜手术用于子宫内膜异位症的疗效及对患者性激素水平和再妊娠的影响[J].武汉大学学报(医学版),2022,43(3):499-502.
[13] 吴利萍,侯伟涛,牛三强,等.宫腔镜下电切术联合GnRH-a在子宫黏膜下肌瘤异常子宫出血患者中的研究[J].中国性科学,2021,30(2):92-96.
[14] 郑永瑜.桂枝茯苓丸联合促性腺激素释放激素激动剂对围绝经期子宫肌瘤合并异常子宫出血患者血清性激素、血管生成素-2水平的影响[J].中国性科学,2021,30(3):112-115.
[15] 王丽娟,汤春辉.GnRH-α联合左炔诺孕酮宫内缓释系统对子宫腺肌症患者疼痛症状、血清MMPs及复发的影响[J].中国计划生育学杂志,2021,29(2):266-270.

[1]	. [J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(8): 1238-1240.