|
|
|
| Psychological, Social, and Iatrogenic Factors Associated with Premature Ovarian Failure in Reproductive-Age Women |
| WANG Yan, WU Xiaohong, LIU Fenqin |
| Xi'an Maternal and Child Health Hospital, Xi'an Shaanxi 710007 |
|
|
|
|
Abstract 【Objective】To investigate the correlation between premature ovarian failure (POF) and psychological, social, and iatrogenic factors in reproductive-age women.【Methods】 A retrospective analysis was conducted on the clinical data of 80 POF patients admitted to the Xi'an Maternal and Child Health Hospital from January 2019 to January 2021 (observation group), and 127 healthy women who underwent health examination in the same period were selected as the control group. General information was compared between the two groups, and multiple factor logistic regression analysis was used to identify risk factors for POF in reproductive-age women. Pearson correlation analysis was used to analyze the correlation between POF and related factors. 【Results】The observation group had significantly higher scores on the Social Anxiety Scale (ASA) and Beck Depression Inventory (BDI), as well as a higher proportion of ovarian surgery history, pelvic surgery history, and use of contraceptives compared to the control group (P<0.05). Multivariate logistic regression analysis showed that social anxiety, depression, ovarian surgery history, pelvic surgery history, and use of contraceptives were risk factors for POF in reproductive-age women (P<0.05). Pearson correlation analysis showed a positive correlation between POF and social anxiety, depression, ovarian surgery history, pelvic surgery history, and use of contraceptives in reproductive-age women (P<0.05). Analysis of the receiver operating characteristic curve showed that social anxiety, depression, ovarian surgery history, pelvic surgery history, and use of contraceptives had high predictive efficiency, with area under the curve of 0.821, 0.871, 0.561, 0.634, and 0.613, respectively. 【Conclusion】The incidence of POF in reproductive-age women is related to factors such as social anxiety, depression, ovarian surgery history, pelvic surgery history, etc. Clinical medical workers need to start with the etiology to develop reasonable treatment plans and thereby improve the reproductive health and quality of life of POF patients in reproductive-age women.
|
|
Received: 30 December 2021
|
|
|
|
|
|
[1] MELEKOGLU R, CIFTCI O, ERASLAN S, et al. Beneficial effects of curcumin and capsaicin on cyclophosphamide-induced premature ovarian failure in a rat model[J].J Ovarian Res,2018,11(1):33.
[2] 周柯宁,何颖颖,范素鸿,等.不同途径补充雌激素对卵巢早衰女性LEEP术后宫颈创面愈合影响的研究[J].中国妇幼保健,2019,34(9):1980-1983.
[3] 周倩,卢永超.卵巢早衰的治疗新进展[J].中国医药导刊,2023,25(1):35-38.
[4] CECCARELLI F,OREFICE V,PERRONE G,et al.Premature ovarian failure in patients affected by systemic lupus erythematosus: A cross-sectional study[J].Clin Exp Rheumatol,2020,38(3):450-454.
[5] 翟康路,卓嘎,兰珍,等.68例早发性卵巢功能不全患者的临床特征分析[J].中国妇产科临床杂志,2018,19(3)81-82.
[6] 乐杰.妇产科学[M].7版.北京:人民卫生出版社,2008:310.
[7] 陈子江,田秦杰,乔杰,等,早发性卵巢功能不全的临床诊疗中国专家共识[J].中华妇产科杂志,2017,52(9):577-581.
[8] 肖红梅,王乐.卵巢早衰的诊治与早期预警研究现状[J].医学临床研究,2020,37(10):1441-1444.
[9] 任玉兰,陈丽萍,李德华,等.梁繁荣教授针灸治疗卵巢早衰性不孕的临床经验总结[J].成都中医药大学学报, 2022, 45(4):59-62.
[10] SPEARS N.LOPES F,STEFANSDOTTIR A,et al.Ovarian damage from chemotherapy and current approaches to its protection[J].Hum Reprod Update,2019,25(6):673-693.
[11] DOMNIZ N,MEIROW D.Premature ovarian insufficiency and autoimmune diseases[J].Best Pract Res Clin Obstet Gynaecol,2019,60:42-55.
[12] 周丽敏,秦秀娟,张炜冉,等.生活方式及心理因素在诱发卵巢早衰中的影响[J].河北医药,2012,34(4):631.
[13] 曾富玲,孙维峰,李静,等.活血滋肾方治疗肾虚血瘀型免疫性卵巢早衰临床观察[J].中国中西医结合杂志,2019,39(5):536-541.
[14] 黎凤鸣.特发性卵巢早衰发病因素的logistic回归分析[J].现代诊断与治疗,2016,27(2):209-210.
[15] 陈剑,仇姝.110例卵巢功能早衰患者的危险因素分析[J].天津医药, 2019,12(6)432-436.
[16] 马艳华,刘晶晶.不孕症患者卵巢早衰的影响因素分析[J].发育医学电子杂志,2015,3(2):83-85.
[17] 施萍,刘淑霞,杨静,等.女性卵巢早衰发生因素分析[J].现代医药卫生,2016,32(19):2960-2962. |
|
|
|
2023, Vol. 40 
