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| Correlation Analysis of Levels of IL-10,IL-17,and ICAM-1 with the Severity of Bronchial Asthma in Children |
| CHEN Chunmei |
| Department of Pediatrics,Xixiang County Traditional Chinese Medicine Hospital,Hanzhong Shaanxi 723500 |
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Abstract 【Objective】To investigate the correlation of levels of interleukin-10 (IL-10),interleukin-17 (IL-17),and intercellular adhesion molecule-1(ICAM-1) with the severity of children bronchial asthma.【Methods】A total of 120 children with bronchial asthma admitted to our hospital from December 2019 to December 2022 were selected as the observation group. According to the severity of bronchial asthma status,patients were further divided into the mild group,the moderate group,and the severe group. In the same time period,60 healthy children who underwent physical examination in our hospital were selected as the control group. The receiver operating characteristic (ROC) curve was used to analyze the value of analyzing the levels of IL-10,IL-17,and ICAM-1 using in predicting the occurrence of bronchial asthma. Spearman rank correlation analysis was applied to analyze the correlation between levels of IL-10,IL-17,ICAM-1 and the severity of the disease.【Results】The level of IL-10 in the observation group was lower than that in the control group (P<0.05),while the levels of IL-17 and ICAM-1 were higher than those in the control group (P<0.05). ROC curve analysis showed that the areas under the curve of IL-10,IL-17,and ICAM-1 in predicting the occurrence of bronchial asthma were 0.868,0.839,and 0.987,respectively (all P<0.05). The trend of IL-10 level was mild group>moderate group>severe group (P<0.05),while the trends of both IL-17 level and ICAM-1 level were in the order of mild group<moderate group<severe group (P<0.05). The level of IL-10 is negatively correlated with the severity of the disease condition (rs=-0.561,P<0.05),while the levels of IL-17 and ICAM-1 were positively correlated with the severity of the disease condition (rs=0.539,0.584,all P<0.05).【Conclusion】IL-10,IL-17,and ICAM-1 have a high predictive value for the occurrence of bronchial asthma in children,and the levels of IL-10,IL-17,and ICAM-1 in children with bronchial asthma are significantly correlated with the severity of the disease. The above indicators can be monitored clinically to predict the occurrence and progression of the disease.
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Received: 16 March 2023
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. [J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(9): 1400-1402. |
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2023, Vol. 40 
