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| Correlation of Prognosis in Patients with Primary Liver Cancer to DC-SIGN,TACC3 and BMP4 Expression in Tissues |
| HOU Zhi-gang, LIU Zhen-hui |
| Department of General Surgery,The Fourth People's Hospital of Shaanxi Province,Xi'an Shaanxi 710061 |
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Abstract 【Objective】 To investigate the prognostic factors of patients with primary liver cancer (PLC).【Methods】 A total of 90 PLC patients were divided into the death group (40 cases) and the survival group (50 cases) according to the three-year prognosis.The basic data and laboratory indicators of the two groups of patients [optical density value of dendritic cell specific intercellular adhesion molecule-3 binding non integrin (DC-SIGN),bone morphogenetic protein 4 (BMP4) level,and positive rate of transcription associated acid curl protein 3 (TACC3)] were collected and compared.DC-SIGN optical density value,TACC3 level and BMP4 positive rate were analyzed by ROC curve to predict the poor prognosis of PLC patients.Unconditional logistic stepwise regression analysis was used to identify the risk factors for poor prognosis of PLC patients.【Results】 The proportion of bilobular tumor distribution,alcohol drinking history,lymph node invasion or distant metastasis,TNM stage Ⅲ-Ⅳ in the death group were significantly higher than those in the survival group (P<0.05),whose DC-SIGN optical density,TACC3 level and BMP4 positive rate were significantly higher than those in the survival group (P<0.05).ROC analysis showed that DC-SIGN optical density ≥10.925×10-3/μm2,TACC3 level ≥331.494 ng/g,and BMP4 positive rate ≥79.883% were the cut-off values for predicting poor prognosis of PLC patients (all P<0.05),respectively.Logistic stepwise regression analysis showed that the bilobular tumor distribution,history of alcohol consumption,lymph node invasion or distant metastasis,TNM stage Ⅲ-Ⅳ,DC-SIGN optical density ≥10.925×10-3/μm2,TACC3 level ≥331.494 ng/g and positive rate of BMP4 ≥79.883% were risk factors for poor prognosis in PLC patients (P<0.05).【Conclusion】 Tumor distribution,drinking history,lymph node invasion,distant metastasis,TNM stage,DC-SIGN optical density value,TACC3 level,BMP4 positive rate were closely related to the prognosis of PLC patients.
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Received: 09 March 2022
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2023, Vol. 40 
