肝硬化并发急性肾损伤患者血清NGAL、cys C及尿KIM-1的表达及其意义

doi:10.3969/j.issn.1671-7171.2022.08.031

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Abstract 【Objective】To investigate the levels of serum neutrophil gelatinase associated lipid carrier protein (NGAL),cysteine protease inhibitor C (cys C) and urinary renal injury factor 1 (KIM-1) in patients with cirrhosis complicated with acute renal injury (AKI) and analyze the risk factors of AKI. 【Methods】A total of 184 patients with liver cirrhosis were divided into the AKI group (n=27) and the non AKI group (n=157) according to whether they were complicated with AKI. The difference between the two groups of patients' basic information and the detection level of relevant laboratory indicators [including hemoglobin (Hb),serum albumin (ALB),white blood cells (WBC),platelet count (PLT),serum alanine aminotransferase (ALT),aspartate aminotransferase (AST),prothrombin activity (PTA),NGAL,cys C,and urinary KIM-1] were collected and compared. The serum NGAL cys C and urinary KIM-1 levels were used to predict the value of AKI in patients with liver cirrhosis. Finally,the different information between the two groups was included in the multivariate logistic regression analysis,and the quantitative assignment was performed to identify the risk factors of AKI in patients with liver cirrhosis. 【Results】There was no significant difference between the two groups in terms of age,sex,body mass index,hypertension,smoking history,classification of liver cirrhosis,etiology of liver cirrhosis,ascites,Hb,ALB,WBC,PLT,PTA,ALT and AST levels (P>0.05).The proportion of patients with AKI combined with diabetes and infection,and the levels of serum NGAL,serum cys C and urinary KIM-1 were significantly higher than those in non AKI group (P<0.05). ROC analysis showed that serum NGAL,cys C and urinary KIM-1 were used to predict AKI in patients with liver cirrhosis. The areas under the curve were 0.854,0.835 and 0.834,respectively,(all P<0.05). Multivariate logistic regression analysis showed that diabetes,infection,serum NGAL,cys C and urinary KIM-1 were independent influencing factors of AKI in patients with liver cirrhosis (P<0.05). 【Conclusion】Serum NGAL,cys C and urinary KIM-1 levels were significantly increased in patients with cirrhosis complicated with AKI,which can be used as sensitive indicators for early prediction of cirrhosis complicated with AKI.

Key words： Liver Cirrhosis/CO Acute Kidney Injury/CO Lipocalin-2/BL Chalones/BL

Received: 10 January 2022

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R571.3

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	DENG Xiang-hai
	HUANG Yu-ying
	HUANG Ning
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Cite this article:

DENG Xiang-hai,HUANG Yu-ying,HUANG Ning, et al. Expression and Significance of Serum NGAL,cys C and Urinary KIM-1 in Patients with Liver Cirrhosis Complicated with Acute Renal Injury[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(8): 1235-1238.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.08.031 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I8/1235

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