Abstract 【Objective】To explore the value of CT perfusion imaging (CTPI) combined with serum triiodothyronine (T3) and free thyroxine (FT4) in the diagnosis of early severe traumatic brain injury (sTBI). 【Methods】 The clinical data of 80 patients with early sTBI admitted to our hospital from January 2018 to December 2021 were retrospectively analyzed. According to the Glasgow Coma Scale (GCS) after admission, they were included in the severe group (n=43) and the mild to moderate group (n=37). Cerebral CTPI was performed in both groups to compare the regional cerebral blood flow parameters and serum T3, FT4 levels in the two groups, and the regional cerebral blood flow parameters and serum T3, FT4 levels and GCS in the severe group. The correlation between GCS and regional cerebral blood flow parameters, serum T3 and FT4 levels was analyzed. 【Results】 The levels of rCBV, rCBF, serum T3 and FT4 in the severe group were lower than those in moderate group, and MTT was higher than that in the mild and moderate group (P<0.05). On the 7th day after operation, the rCBV, rCBF, GCS scores, serum T3 and FT4 levels in the severe group were higher than those on the next day after admission, and the MTT was higher than that on the next day after admission. The difference was statistically significant (P<0.05). Pearson correlation analysis showed that GCS was negatively correlated with rCBV and serum T3 and FT4 levels (r=-0.4003,-0.6841,-0.7136,all P<0.05), but not with rCBF and MTT (P>0.05). 【Conclusion】 The combination of brain CTPI and serum T3, FT4 in the diagnosis of early sTBI is helpful to evaluate the degree of brain injury and to improve the diagnostic accuracy.
LIU Ben,LI Yan-long,LU Zhi-wei, et al. Application Value of CT Perfusion Imaging Combined with Serum T3 and FT4 in Diagnosis of Early Severe Traumatic Brain Injury[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(8): 1221-1223.
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2022, Vol. 39 
