HIF-1α、NLRP3、Adropin与高血压脑出血血肿清除术后并发脑梗死患者神经缺损的相关性

doi:10.3969/j.issn.1671-7171.2022.07.007

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Abstract 【Objective】 To investigate the relationship of hypoxia-inducible factor-1α (HIF-1α), nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) and Adropin with nerve defects in patients with hypertensive intracerebral hemorrhage (HICH) complicated with brain infarction after hematoma removal. 【Methods】A total of 151 patients with cerebral infarction after HICH hematoma removal in our hospital from June 2018 to March 2021 were selected and divided into the poor prognosis group (n=34) and the good prognosis group (n=117) according to the 30-day prognosis. The baseline data, the National Institutes of Health Stroke Scale (NIHSS) and HIF-1α, NLRP3, Adropin (before and 3 days after surgery) were compared between the two groups. Pearson analysis was used to analyze the correlation of HIF-1α, NLRP3 and Adropin with NIHSS scores. Cox regression analysis, receiver operating characteristic curve (ROC) and ROC area (AUC) analysis predicted prognosis value of HIF-1α, NLRP3 and Adropin. 【Results】The volume of hematoma in the poor group was higher than that of the good group, and the GCS score at admission was lower than that of the good group (P<0.05). Compared with preoperative, serum HIF-1α and NLRP3 levels in both groups were increased on 3 days after operation, while Adropin and NIHSS scores were decreased in both groups. The levels of HIF-1α, NLRP3, and NIHSS scores of the poor group were higher than those of the good group at 3 days postoperatively, and Adropin was lower than the good group (P<0.05). HIF-1α and NLRP3 were positively correlated with NIHSS score (r=0.550, 0.659, both P<0.05), and Adropin was negatively correlated with NIHSS score (r=-0.679, P<0.05). The ROC curve results showed that HIF-1α, NLRP3 combined with Adropin had the highest AUC, sensitivity and specificity in predicting poor prognosis 3 days after operation. 【Conclusion】HIF-1α, NLRP3, and Adropin are related to the neurological deficit and prognosis of patients with cerebral infarction after HICH hematoma removal. Combined detection can be used as an effective prognosis prediction plan and provide a reference for clinical prevention of disease deterioration and treatment.

Key words： Intracranial Hemorrhage, Hypertensive/SU Hematoma/SU Brain Infarction Hypoxia-Inducible Factor 1, alpha Subunit

Received: 15 September 2021

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R544.1

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.07.007 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I7/984

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