HIF-1α、VEGF在口腔癌组织中的表达水平及其临床意义

doi:10.3969/j.issn.1671-7171.2022.07.002

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Abstract 【Objective】 To investigate the expression and clinical significance of hypoxia inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in oral cancer tissues. 【Methods】A total of 174 patients with oral cancer who were treated by the Fourth Hospital of Yulin City, Shaanxi Province from May 2014 to February 2016 were selected as the research objects. During the operation, adjacent tissues (>3 cm from the edge of tumor tissue) and cancer tissues were collected. Immunohistochemical method was used to detect the expression of HIF-1α and VEGF in cancer tissues and adjacent tissues of oral cancer patients. General patient data were collected. The relationship of HIF-1α and VEGF expression levels in the cancer tissues of oral cancer patients with the clinicopathological characteristics were analyzed. After 5 years of follow-up, Kaplan-Meier method was used to draw the survival curve, and the Log-rank test was used to test the difference in survival curves of HIF-1α positive vs HIF-1α negative patients, and VEGF positive vs VEGF negative patients. 【Results】The positive rates of HIF-1α and VEGF in cancer tissues of oral cancer patients were higher than those in adjacent tissues (P<0.05). The expression of HIF-1α and VEGF in the cancer tissues of oral cancer patients were related to lymph node metastasis, tumor size, clinical stage, and tumor differentiation (P<0.05), but not related to gender, age, blood vessel invasion, nerve invasion, and location of disease (P>0.05). The 5-year survival rate of HIF-1α-negative patients is higher than that of HIF-1α-positive patients (P<0.05). The median survival time of HIF-1α-negative was 42.63 months, which was longer than that of HIF-1α-positive patients (25.01 months). There was a statistically significant difference between the survival curves of the two population (P<0.05). The 5-year survival rate of VEGF-negative patients was higher than that of VEGF-positive patients (P<0.05). The median survival time of VEGF-negative and VEGF-positive patients was 45.84 months and 16.94 months,respectively, and the difference in survival curves was statistically significant (P<0.05). 【Conclusion】The positive rates of HIF-1α and VEGF in the cancer tissues of patients with oral cancer are relatively higher, which are related to lymph node metastasis, tumor size, clinical stage, and degree of tumor differentiation. The detection of both HIF-1α and VEGF expression can help predict the prognosis in oral cancer patients.

Key words： Mouth Neoplasms/PA Hypoxia-Inducible Factor 1, alpha Subunit Vascular Endothelial Growth Factor A

Received: 16 February 2022

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R739.8

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	HOU Xiao-feng
	FENG Wen-zhen

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HOU Xiao-feng,FENG Wen-zhen. Expression and Clinical Significance of HIF-1α and VEGF in Oral Cancer Tissues[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(7): 965-968.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.07.002 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I7/965

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