慢性肝功能衰竭合并细菌感染患者血清PTX3、HBP水平及其预测患者预后的临床价值

doi:10.3969/j.issn.1671-7171.2022.06.032

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Abstract 【Objective】To investigate the levels of serum pentamerin 3 (PTX3) and heparin binding protein (HBP) in patients with chronic liver failure (CLF) complicated with bacterial infection and their clinical value in predicting prognosis. 【Methods】A total of 138 patients with CLF admitted to Department of General Surgery,Affiliated Hospital of Xi'an Medical College from March 2018 to March 2020 were selected and divided into observation group (with bacterial infection,n=58) and control group (without bacterial infection,n=80) according to whether they were complicated with bacterial infection. The levels of serum PTX3 and HBP were detected by enzyme-linked immunosorbent assay (ELISA),and the relationship between the expression levels of serum PTX3 and HBP and clinicopathological features was analyzed. The levels of serum PTX3 and HBP in patients with different prognosis were compared; ROC curve was used to analyze the diagnostic value of serum PTX3 and HBP levels in patients with poor prognosis. 【Results】The levels of serum PTX3 and HBP in the observation group were significantly higher than those in the control group (P<0.05). There was no significant difference in age,sex and diabetes among patients with different serum PTX3 and HBP levels (P>0.05);There were significant differences in clinical stages,MELD scores and compl ications (P<0.05). The levels of serum PTX3 and HBP in the death group were significantly higher than those in the survival group (P<0.05). The area under curve (AUC) of serum PTX3 in predicting poor prognosis was 0.876,the sensitivity was 92.1%,and the specificity was 80.0%; The AUC of serum HBP in predicting poor prognosis was 0.893,the sensitivity was 71.1%,and the specificity was 95.0%; The AUC predicted by the two methods was 0.959,the sensitivity was 84.2%,and the specificity was 95.0%. 【Conclusion】 Serum PTX3 and HBP are highly expressed in patients with CLF complicated with bacterial infection. The high expression of PTX3 and HBP is related to the poor prognosis of patients. It is a potential biological index to diagnose the prognosis of patients.

Key words： Liver Failure/CO Bacterial Infections/CO Polyproteins/BL Carrier Proteins/BL Prognosis

Received: 06 December 2021

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R575.3

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	WANG Ming
	WU Yan-ling

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WANG Ming,WU Yan-ling. Serum PTX3 and HBP Levels in Patients with Chronic Liver Failure Complicated with Bacterial Infection and their Clinical Value in Predicting Prognosis[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(6): 921-924.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.06.032 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I6/921

[1] 柯坤宇,潘晨,陈丽芳,等. 尿肾损伤分子-1对慢加急性(亚急性)肝功能衰竭患者并发急性肾损伤的早期诊断价值[J].中华传染病杂志,2018,36(10):627-629.
[2] 高佳师,许振宇,李琎,等. 肝衰竭继发感染的预后分析[J].中华传染病杂志,2019,37(5):271-274.
[3] YAMAGUCHI S,MAEDA S,YONISHI H,et al. Plasma pentraxin 3 (PTX3) level is associated with the disease activity of microscopic polyangiitis (MPA)[J].Nihon Jinzo Gakkai Shi,2017,59(2):79-84.
[4] 张春云,何耀军,江雁琼. 慢性阻塞性肺疾病急性加重期HBP和CD64表达与不同细菌感染的关系[J].广东医学,2017,38(12):1842-1844.
[5] 中华医学会感染病学分会肝衰竭与人工肝学组,中华医学会肝病学分会重型肝病与人工肝学组. 肝衰竭诊疗指南[J].中华肝脏病杂志,2006,14(9):643-646.
[6] 陆忠华,甘建和. 肝衰竭患者的免疫状态及其免疫调控治疗[J].中华肝脏病杂志,2017,25(9):641-645.
[7] 韩英,崔丽娜,郭冠亚. 慢加急性肝衰竭的免疫治疗[J].临床肝胆病杂志,2017,33(9):1677-1682.
[8] 代琴棋,周延,陆钊,等. 慢加急性肝衰竭患者并发上消化道出血的危险因素分析[J].国际流行病学传染病学杂志,2020,47(2):162-165.
[9] 杨雁华,汤建民,来桂棵,等. 正五聚蛋白3对血管紧张素Ⅱ刺激后血管内皮细胞凋亡及血管活性物质分泌的影响[J].中国老年学,2019,39(9):150-154.
[10] BALHARA J,SHAN L,ZHANG J,et al. Pentraxin 3 deletion aggravates allergic inflammation through a TH17-dominant phenotype and enhanced CD4 T-cell survival[J].J Allergy Clin Immunol,2017,139(3):950-963.
[11] TAZAKI R,TANIGAWA J,FUJISAKA T,et al. Plasma pentraxin 3 level is associated with plaque vulnerability assessed by optical coherence tomography in patients with coronary artery disease[J].Int Heart J,2016,57(1):18-24.
[12] TIAN R,WANG X,PAN T,et al. Plasma PTX3,MCP1 and Ang2 are early biomarkers to evaluate the severity of sepsis and septic shock[J].Scand J Immunol,2019,90(6):e12823.
[13] 王卓,纪卫华,王雨新,等. 肝素结合蛋白在新生儿早期细菌感染性疾病诊断中的应用价值[J].中华检验医学杂志,2016,39(12):972-973.
[14] FISHER J,LINDER A. Heparin-binding protein:a key player in the pathophysiology of organ dysfunction in sepsis[J].J Intern Med,2017,281(6):562-574.