Abstract 【Objective】To investigate the correlation between levels of serum heparin binding epidermal growth factor (HB-EGF) and hypoxia inducible factor-1α (HIF-1α) in children with lupus nephritis and its prognosis.【Methods】 A total of 70 children with lupus nephritis (observation group) admitted to the first Yulin hospital from July 2016 to July 2018 were followed up for 18~36 months. The children were divided into good prognosis group (n=55) and poor prognosis group (n=15) according to whether there were composite renal end points at the end of follow-up. A total of 50 healthy children who underwent physical examination in our hospital at the same time were selected as the control group. Levels of the serum HB-EGF and HIF-1α of subjects in different groups were measured at admission. The subjects's operating characteristic curve (ROC curve) and the area under curve (AUC) were used to evaluate the predictive value of their expression levels on the prognosis of children with lupus nephritis,and logistic regression analysis was performed on the related factors affecting the prognosis of children with lupus nephritis.【Results】The levels of serum HB-EGF and HIF-1α in the observation group were significantly higher than those in the control group(P<0.05). The levels of serum creatinine,blood urea nitrogen,serum HB-EGF and HIF-1αin the poor prognosis group were significantly higher than those in the group with good prognosis (P<0.05). The expression level of the area under the curve (AUC) of serum HB-EGF and HIF-1α were 0.869 and 0.822 respectively,the cut-off values were 39.692 pg/mL and 97.448 ng/L respectively,the sensitivity were 86.70% and 66.70% respectively,and the specificity were 76.40% and 92.70% respectively; The combined AUC was 0.937,the sensitivity and specificity were 80.00% and 96.40%. Logistic analysis showed that high levels of serum HB-EGF and HIF-1α were independent risk factors influencing the prognosis of children with lupus nephritis.【Conclusion】 The levels of serum HB-EGF and HIF-1α in children with lupus nephritis has increased significantly,and its expression level has a certain predictive value for the prognosis of children with lupus nephritis.
LIU Yan,SUN Cai-xia. Correlation between of Levels of Serum HB-EGF and HIF-1α and its Prognosis in Children with Lupus Nephritis[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(6): 925-928.
[1] ALLEN M E,RUS V,SZETO G L. Leveraging heterogeneity in systemic lupus erythematosus for new therapies[J].Trends Mol Med,2020,9(20):30256-30262.
[2] 党西强,易著文.狼疮性肾炎诊治循证指南(2016)解读[J].中华儿科杂志,2018,56(2):95-99.
[3] 刘美兰,马福哲,吴昊,等. 狼疮性肾炎患者血清IL-18、IL-34水平及其意义[J].中国现代医学杂志,2018,28(2):53-56.
[4] DAO D T,ANEZ B L,ADAM R M,et al. Heparin-binding epidermal growth factor-like growth factor as a critical mediator of tissue repair and regeneration[J].Am J Pathol,2018,188(11):2446-2456.
[5] 李敏,郭毅飞,龚丽,等. 狼疮肾炎患者尿液低氧诱导因子-1α和生长转化因子-β1的变化及意义[J].疑难病杂志,2019,18(8):813-817.
[6] PETRI M,ORBAI A M,ALARCÓN G S,et al. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus[J].Arthritis Rheum,2012,64(8):2677-2686.
[7] 中华医学会儿科学分会肾脏病学组.儿童常见肾脏疾病诊治循证指南(试行)(六):狼疮性肾炎诊断治疗指南[J].中华儿科杂志,2010,48(9):687-690.
[8] GLADMAN D D,IBAÑEZ D,UROWITZ M B. Systemic lupus erythematosus disease activity index 2000[J].J Rheumatol,2002,29(2):288-291.
[9] 赵韶静,曾艳,李正东. 狼疮性肾炎患者IL-15表达情况及免疫病理损伤特点[J].免疫学杂志,2019,35(5):439-443.
[10] EAPEN M S,SHARMA P,THOMPSON I E,et al. Heparin-binding epidermal growth factor (HB-EGF) drives EMT in patients with COPD:implications for disease pathogenesis and novel therapies[J].Lab Invest,2019,99(2):150-157.
[11] 黄美春,黄荣桂. HB-EGF对系膜细胞增殖及转化生长因子-β1表达的影响[J].中国中西医结合肾病杂志,2008,9(3):260-261.
[12] TAHEEM D K,FOYT D A,LOAIZA S,et al. Differential regulation of human bone marrow mesenchymal stromal cell chondrogenesis by hypoxia inducible factor-1α hydroxylase inhibitors[J].Stem Cells,2018 ,36(9):1380-1392.
[13] 李会娟,曾莉,卿山林,等. 血清HIF-1α水平与慢性肾小球肾炎患者病情严重程度的相关性分析[J].热带医学杂志,2020,20(6):799-802.
2022, Vol. 39 
