血清sTREM-1、PCT水平及APACHEⅡ、MODS评分与老年重症肺炎伴呼吸衰竭患者预后的相关性分析

doi:10.3969/j.issn.1671-7171.2022.06.021

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Abstract 【Objective】 To investigate the correlation between serum soluble myeloid cell trigger receptor (sTREM-1),procalcitonin (PCT),acute physiology and chronic health score Ⅱ (APACHEⅡ),multiple organ dysfunction score (MODS) and the prognosis of elderly patients with severe pneumonia (SP) and respiratory failure (RF).【Methods】 The clinical data of 164 patients with SP and RF diagnosed and treated in our hospital from April 2019 to April 2021 were retrospectively analyzed. After admission,all patients received routine treatment such as anti infection,expectoration,correction of water and electrolyte. According to the treatment effect,the patients were divided into good prognosis group (significantly effective + effective,n=92) and poor prognosis group (n=72). The basic data of the two groups were compared [gender,age,body mass index (BMI),residential area,smoking history,drinking history,history of immunosuppressant or glucocorticoid use,combined diseases (hypertension,diabetes,chronic obstructive pulmonary disease,hyperlipidemia),mechanical ventilation,RF classification,acute physiology and APACHE Ⅱ score,MODS score] and laboratory indicators (sTREM-1,PCT) difference. The predictive value of age,APACHE Ⅱ score,MODS score,sTREM-1 and PCT level on the prognosis of patients with SP and RF was analyzed by receiver operating characteristic (ROC) curve. The risk factors for poor prognosis of patients with SP and RF were analyzed by multivariate logistic regression.【Results】 Among the 164 patients,56.10% (92/164) had a good prognosis and 43.90% (72/164) had a poor prognosis. There was no significant difference between the two groups in terms of gender,BMI,residential area,drinking history,history of immunosuppressant or glucocorticoid use,hypertension,chronic obstructive pulmonary disease,hyperlipidemia and RF classification (P>0.05); The proportion of patients with smoking history,diabetes and mechanical ventilation in the poor prognosis group was significantly higher than that in the good prognosis group(P>0.05). ROC curve analysis showed that age,APACHE Ⅱ score,MODS score,sTREM-1 and PCT could predict the prognosis of patients with SP and RF. The results of multivariate logistic regression analysis showed that:smoking history,diabetes,mechanical ventilation,age ≥ 76 years,Apache Ⅱ score ≥ 17.880,MODS score ≥ 9.835,sTREM-1 ≥ 81.375 ng/L,PCT ≥ 22.220 μg/L were risk factors for poor prognosis in patients with SP and RF.【Conclusion】Serum sTREM-1,PCT,APACHE Ⅱ and MODS scores can affect the prognosis of patients with SP and RF. When APACHE Ⅱ score≥17.880,MODS score≥9.835,sTREM-1≥81.375 ng/L,PCT≥22.220 μg/L can predict the prognosis of such patients.

Key words： Pneumonia/CO Respiratory Insufficiency/CO Calcitonin/AN Membrane Glycoproteins/AN Aged Prognosis

Received: 14 January 2022

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R563.1

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	YU Cong-yi
	LONG Yi-wen

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YU Cong-yi,LONG Yi-wen. Correlation between Serum Levels of sTREM-1,PCT,APACHE Ⅱ,MODS and Prognosis of Elderly Patients with Severe Pneumonia and Respiratory Failure[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(6): 877-880.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.06.021 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I6/877

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