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| Clinical Efficacy of Ivabradine Combined with Sodium Aescinate in the Treatment of Senile Heart Failure Complicated with Chronic Obstructive Pulmonary Disease |
| ZENG Xin-chun, LI Jin-ke |
| Department of Cardiovascular Medicine, Eastern Hospital, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Shaanxi 710089 |
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Abstract 【Objective】 To investigate the clinical efficacy of ivabradine combined with sodium aescinate in elderly patients with heart failure complicated with chronic obstructive pulmonary disease (COPD). 【Methods】 A total of 92 elderly patients with heart failure complicated with COPD treated in the First Affiliated Hospital of Xi'an Jiaotong University from March 2019 to June 2020 were randomly divided into observation group (treated with ivabradine combined with sodium aescinate) and control group (treated with ivabradine), with 46 cases in each group. The cardiac function, pulmonary function and exercise endurance of the two groups were compared before and after treatment, and the adverse reactions of the two groups were recorded. 【Results】After treatment, the left ventricular ejection fraction, left ventricular end diastolic diameter, left ventricular end diastolic volume and ventricular septal diastolic thickness in the two groups were higher than those before treatment, and the difference between the observation group and the control group was statistically significant (P<0.05); The forced vital capacity, forced expiratory volume in the first second and 6-minute walking distance of the two groups were higher than those before treatment (P<0.05), and the observation group was higher than that of the control group (P<0.05). The incidence of adverse reactions in the observation group was 13.04% (6/46), higher than 8.70% (4/46) in the control group, but the difference was not statistically significant (χ2=0.45=0.45, P=0.50>0.05). 【Conclusion 】Ivabradine combined with sodium aescinate can significantly improve the heart and lung function and exercise endurance of elderly patients with heart failure and COPD, with good safety and certain clinical value.
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Received: 02 September 2021
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2022, Vol. 39 
