Abstract 【Objective】To investigate the clinical characteristics,drug resistance and prognosis of ventilator-associated pneumonia (VAP) caused by Candida albicans combined with Acinetobacter baumannii. 【Methods】A total of 128 patients with VAP caused by Candida albicans combined with Acinetobacter baumannii who were admitted to our hospitals from March 2018 to July 2021 were selected as the research objects. The clinical characteristics and drug resistance of the patients were analyzed. After 4 weeks of follow-up,the factors for patient prognosis were analyzed as well. 【Results】The clinical features of 128 patients with VAP caused by Candida albicans combined with Acinetobacter baumannii were mostly cough,expectoration,dyspnea,fever,and blisters in the lungs. Candida albicans strains are more sensitive to mycotoxins and clotrimazole,whose resistance rates were 0 and 6.25%,respectively. However,the resistance rates to other antibiotics were all >10%. Acinetobacter baumannii strains were sensitive to tigecycline and minocycline,with resistance rates of 0 and 23.44%,respectively. And its resistance rates to other antibiotics were all >30%. Logistic multivariate regression analysis showed that albumin,acute physiology and chronic health evaluation score Ⅱ(APACHE Ⅱ),clinical pulmonary infection score (CPIS),secondary tracheal intubation,antibiotic use time were factors that affected the prognosis of VAP patients caused by candida combined with acinetobacter baumannii (P<0.05). 【Conclusion】The clinical characteristics of patients with VAP caused by candida albicans combined with acinetobacter baumannii are diverse,and they are highly resistant to a variety of commonly used antibiotics. The first choices for clinical treatment of VAP caused by candida albicans combined with acinetobacter baumannii were mycotoxins,clotrimazole,tigecycline and minocycline. Albumin,APACHE Ⅱ score,CPIS score,secondary tracheal intubation,antibiotic use time are the factors that affect the prognosis of patients with VAP caused by Candida and Acinetobacter baumannii.
LIU Cui-ying,ZHANG Chun-feng,XU Xian-biao. Clinical Characteristics,Drug Resistance and Prognosis of VAP Caused by Candida Albicans Combined with Acinetobacter Baumannii[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(10): 1493-1496.
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2022, Vol. 39 
