妊娠期高血压患者糖脂代谢特点及其与妊娠结局的关系

doi:10.3969/j.issn.1671-7171.2022.10.011

Abstract
Figure/Table
References (0)
Related Citation (15)

Download: PDF (1118 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To investigate the characteristics of lipid metabolism in patients with gestational hypertension and its relationship with pregnancy outcomes. 【Methods】From December 2019 to December 2021,80 patients with gestational hypertension who were admitted to the Obstetrics and Gynecology Department of Zhashui County People's Hospital,Shangluo City,Shaanxi Province were selected as the observation group,and 80 pregnant women who underwent physical examination during the same period were selected as the control group. The levels of glucose metabolism [fasting blood glucose (FPG),glycosylated hemoglobin (HbA1c)],lipid metabolism indexes [triglyceride (TG),total cholesterol (TC),low-density lipoprotein cholesterol (LDL-C),High-density lipoprotein cholesterol (HDL-C)] levels and pregnancy outcomes in the observation group and the control group were compared. According to the severity of gestational hypertension,the observation group was divided into the mild group (n=53) and the severe group (n=27). The glucose,lipid metabolism and adverse pregnancy outcomes were compared between the mild and severe groups. Thus,the correlation of the metabolism of glucose and lipid to adverse pregnancy outcomes in patients with blood pressure was analyzed. 【Results】The levels of HbA1c,FPG,TC,TG and LDL-C in the observation group were significantly higher than those in the control group (P<0.05),while the level of HDL-C was lower than those in the control group (P<0.05). The incidence rates of premature birth,macrosomia,fetal distress,postpartum hemorrhage,oligohydramnios,premature rupture of membranes,polyhydramnios,cesarean section,and low-quality infants in the observation group higher than the control group (P<0.05). The levels of HbA1c,FPG,TC,TG and LDL-C in the severe group were higher than those in the mild group (P<0.05),while the level of HDL-C was lower than those in the mild group (P<0.05). In the severe group,the incidence rates of premature birth,macrosomia,fetal distress,postpartum hemorrhage,oligohydramnios,premature rupture of membranes,polyhydramnios,cesarean section,and low-quality infants were higher than those of the mild group (P<0.05). The Spearman test showed that the levels of FPG,HbA1c,TG,TC,and LDL-C in patients with gestational hypertension were positively correlated with adverse pregnancy outcomes (P<0.05),and the level of HDL-C was negatively correlated with adverse pregnancy outcomes (P<0.05). 【Conclusion】The glucose and lipid metabolism in patients with gestational hypertension is significantly abnormal,which is closely related to adverse pregnancy outcomes.

Key words： Hypertension, Pregnancy-Induced Glycolipids/ME Pregnancy Outcome

Received: 18 April 2022

PACS:

R581.2

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	XIA Ting-e
	SUN Bei

Cite this article:

XIA Ting-e,SUN Bei. Characteristics of Lipid Metabolism in Patients with Gestational Hypertension and Its Relationship with Pregnancy Outcomes[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(10): 1478-1481.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.10.011 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I10/1478

[1] 王和平,刘光莲. IL-6、sFlt-1、VEGF在妊娠期高血压孕妇血清中的表达及其临床意义[J].医学临床研究,2021,38(5):656-663.
[2] 金铭,刘晓静,张子怡,等. 妊娠期高血压疾病的代谢组学研究进展[J].中国生育健康杂志,2022,33(1):62-67.
[3] 陈文水,林华东,郭培琴. 妊娠期高血压疾病5,10-亚甲基四氢叶酸还原酶基因多态性与脂代谢的相关性分析[J].中国妇幼保健,2019,34(10):2306-2309.
[4] 曹泽毅.妇产科学[M].北京:人民卫生出版社,2008:76-170.
[5] 中华医学会妇产科学分会妊娠期高血压疾病学组. 妊娠期高血压疾病诊治指南(2015)[J].中华围产医学杂志,2016,19(3):161-169.
[6] TANGREN J S,POWE C E,ECKER J,et al. Metabolic and hypertensive complications of pregnancy in women with nephrolithiasis[J].Clin J Am Soc Nephrol,2018,13(4):612-619.
[7] 林楠,顾玮,侯燕燕. 妊娠期高血压疾病孕妇孕早期血脂代谢研究[J].中国妇幼保健,2019,34(16):3641-3644.
[8] 李骏,徐莺,胡峥. 抗心磷脂抗体与妊娠期高血压疾病严重程度和母婴结局的相关性[J].医学临床研究,2020,37(7):1011-1013.
[9] 赵立梅,晏秋雨,谢娟,等. 妊娠期糖尿病合并妊娠期高血压疾病孕妇的血脂分布特征分析[J].中国慢性病预防与控制,2019,27(3):192-196.
[10] 黄思玲,桑琳. 孕期体质量增值、血脂水平与孕妇妊娠期高血压靶器官损害及妊娠结局的关联性分析[J].蚌埠医学院学报,2021,46(7):907-912.
[11] 孙文艳,李长贵,张辉,等. 妊娠晚期血尿酸与不良妊娠结局的相关性研究[J].中华内科杂志,2021,60(5):446-452.
[12] 刘丽丽,刘静. 妊娠期高血压患者HLA-Ⅰ、miR-95-5p表达及与母婴不良结局相关性[J].中国计划生育学杂志,2022,30(1):172-176.
[13] 李骏,徐莺,胡峥. 抗心磷脂抗体与妊娠期高血压疾病严重程度和母婴结局的相关性[J].医学临床研究,2020,37(7):1011-1013.
[14] 郭欣,刘清,方芳,等. 妊娠期高血压患者血脂和凝血指标变化及与围产期结局的关系[J].中国慢性病预防与控制,2017,25(3):229-231.