Abstract 【Objective】To explore the clinical effects of treating postmenopausal syndrome after endocrine therapy of breast cancer with Chinese medicine way of Hefa (harmonic herbs). 【Methods】A total of 78 patients with menopausal syndrome after endocrine therapy of breast cancer from January 2018 to January 2020 in our hospital were selected for the study. All patients were divided into the observation group and the control group by random number table method, with 39 cases respectively. The control group was treated with endocrine drugs, oryzanol tablets and vitamin B1 at the same time. The observation group was treated with traditional Chinese medicine way of Hefa (harmonic herbs) on the basis of the control group. The clinical efficacy, TCM syndrome score, serum sex hormones [estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH)], tumor markers [carbohydrate antigen 15-3 (CA15-3), carbohydrate antigen 125 (CA125)] were compared between the two groups before and after treatment. 【Results】The total effective rate of the observation group was 92.31%, which was significantly higher than 74.36% of the control group (P<0.05).There was no significant difference in TCM syndrome score between the two groups before treatment (P>0.05). After treatment, the scores of menstrual disorder, hot flashes and sweating, emotional changes, dizziness and tinnitus, waist and knee soreness, palpitation and insomnia in the observation group were significantly lower than those before treatment and after treatment in the control group, and the difference was statistically significant (P<0.05).There were no significant differences in the levels of E2, LH, FSH, CA15-3 and CA125 between and within the two groups before and after treatment (P>0.05). 【Conclusion】After endocrine therapy of breast cancer, patients with menopausal like syndrome can be treated with traditional Chinese medicine way of Hefa (harmony) to significantly relieve the clinical symptoms of patients without significant impact on sex hormones and tumor markers.
WU Xiao-mei,LUO He-ting,LIU Mi-hua, et al. Study on Chinese Medicine Way of Hefa (Harmonic Herbs) in the Treatment of Menopausal Syndrome after Endocrine Therapy of Breast Cancer[J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(9): 1334-1337.
2021, Vol. 38 
