Abstract 【Objective】To explore the bacterial distribution and drug sensitivity analysis of nasal secretions in children with chronic rhinosinusitis (CRS). 【Methods】A total of children with CRS and healthy children in the same period were selected. Nasal secretions were collected from two groups to detect the distribution of bacteria, fasting peripheral blood was collected to detect the level of serum IgE, and the drug sensitivity of bacteria isolated from children was analyzed by K-B disk agar diffusion method.【Results】The positive rate of bacterial culture in the observation group was 70.49% (43/61), and the positive rate of serum IgE was 75.41% (46/61), which was significantly higher than 3.28% (2/61) and 1.64% (1/61) in the control group (P<0.05); Spearman correlation analysis showed that the positive rate of serum IgE was positively correlated with the positive rate of bacteria in nasal secretions (r=0.549, P<0.05). A total of 53 strains of bacteria were cultured from nasal secretions of children, of which 15 children (24.59%, 15/61) were infected with more than two kinds of bacteria, 16 strains of bacteria producing β- Lactamase (β- LPB) (30.19%, 16/53); There were 29 strains of Gram-positive bacteria, accounting for 54.72% (29/53), and 24 strains of Gram-negative bacteria, accounting for 45.28% (24/53). Among them, Haemophilus influenzae, Streptococcus pyogenes and Streptococcus pneumoniae accounted for a high proportion. The antibiotics with high sensitivity of 29 Gram-positive bacteria were linezolid, archamycin, vancomycin, rifampicin and cefuroxime, and the antibiotics with high sensitivity of 24 Gram-negative bacteria were amikacin, cefoperazone, sulbactam, imipenem, aztreonam and ceftazidime. 【Conclusion】 There is a positive correlation between bacterial positive nasal secretion and serum IgE positive in children with CRS, which may participate in the occurrence and development of CRS. Gram positive bacteria and gram negative bacteria in nasal secretions of children with CRS are highly sensitive to most antibiotics. The drug sensitivity results have important reference value for antibiotic treatment of CRS.
XU Xue-feng,LIU Hui,YAO Lei. Bacterial Distribution and Drug Sensitivity Analysis of Nasal Secretions in Children with Chronic Rhinosinusitis[J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(8): 1194-1197.
2021, Vol. 38 
