医学临床研究
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JOURNAL OF CLINICAL RESEARCH  2021, Vol. 38 Issue (7): 975-977    DOI: 10.3969/j.issn.1671-7171.2021.07.004
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Application Value of Budesonide Combined with Endotracheal Intubation, Active Substances on the Lung Surface, Extubation and Continuous Positive Airway Pressure Ventilation in Premature Infants with Respiratory Distress Syndrome
ZHU Xi-yi, LI Liu-qing, LI Fu-bing,et al
Department of Pediatrics, the People's Hospital of Guangxi Zhuang Autonomous Regin, Nanning 530021, China
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Abstract  【Objective】To explore the use of Application value of budesonide combined with endotracheal intubation, active substances on the lung surface, extubation and continuous positive airway pressure ventilation in premature infants with respiratory distress syndrome. 【Methods】The clinical data of 30 premature infants with NRDS treated in our hospital from January 2018 to December 2019 were retrospectively analyzed. According to different treatment methods, they were divided into observation group and control group, with 15 cases in each group. Both groups were treated with insert technology, and the observation group was treated with budesonide. The blood gas analysis indexes, PS reuse rate, average weaning time, average total oxygen inhalation time, incidence and severity of BPD were compared between the two groups, and the complications during treatment were recorded and compared between the two groups. 【Results】 At 12 h and 24 h after administration, the levels of ph and PaCO2 in the two groups were higher than those at 4 h after administration, and those in the observation group were higher than those in the control group; The level of PaCO2 in the two groups was lower than 4 hours after administration, and the level of PaCO2 in the observation group was lower than that in the control group(mean P<0.05). The reuse rate of PS, the incidence of BPD and the proportion of moderate to severe BPD in the observation group were lower than those in the control group(P<0.05). After CPAP treatment, the average withdrawal time and average total oxygen inhalation time in the observation group were lower than those in the control group(P<0.05). There was no significant difference in the incidence of retinopathy, late-onset sepsis, necrotizing enterocolitis and periventricular intraventricular hemorrhage between the two groups(P>0.05).【Conclusion】Budesonide combined with insert technology in the treatment of respiratory distress syndrome of preterm infants can effectively improve the blood gas index of children, improve the treatment effect, reduce the occurrence of BPD in preterm infants, and do not increase the risk of complications during treatment. It is worthy of popularization and application.
Key wordsRespiratory Distress Syndrome, Newborn/TH      Positive-Pressure Respiration      Pulmonary Surfactants      Budesonide/TU     
Received: 19 May 2020     
PACS:  R725.638  
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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2021.07.004     OR     http://journal07.magtech.org.cn/yxlcyj/EN/Y2021/V38/I7/975
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