布地奈德联合气管插管-肺表面活性物质-拔管使用持续气道正压通气技术在早产儿呼吸窘迫综合征的应用价值

doi:10.3969/j.issn.1671-7171.2021.07.004

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Abstract 【Objective】To explore the use of Application value of budesonide combined with endotracheal intubation, active substances on the lung surface, extubation and continuous positive airway pressure ventilation in premature infants with respiratory distress syndrome. 【Methods】The clinical data of 30 premature infants with NRDS treated in our hospital from January 2018 to December 2019 were retrospectively analyzed. According to different treatment methods, they were divided into observation group and control group, with 15 cases in each group. Both groups were treated with insert technology, and the observation group was treated with budesonide. The blood gas analysis indexes, PS reuse rate, average weaning time, average total oxygen inhalation time, incidence and severity of BPD were compared between the two groups, and the complications during treatment were recorded and compared between the two groups. 【Results】 At 12 h and 24 h after administration, the levels of ph and PaCO₂ in the two groups were higher than those at 4 h after administration, and those in the observation group were higher than those in the control group; The level of PaCO₂ in the two groups was lower than 4 hours after administration, and the level of PaCO₂ in the observation group was lower than that in the control group(mean P<0.05). The reuse rate of PS, the incidence of BPD and the proportion of moderate to severe BPD in the observation group were lower than those in the control group(P<0.05). After CPAP treatment, the average withdrawal time and average total oxygen inhalation time in the observation group were lower than those in the control group(P<0.05). There was no significant difference in the incidence of retinopathy, late-onset sepsis, necrotizing enterocolitis and periventricular intraventricular hemorrhage between the two groups(P>0.05).【Conclusion】Budesonide combined with insert technology in the treatment of respiratory distress syndrome of preterm infants can effectively improve the blood gas index of children, improve the treatment effect, reduce the occurrence of BPD in preterm infants, and do not increase the risk of complications during treatment. It is worthy of popularization and application.

Key words： Respiratory Distress Syndrome, Newborn/TH Positive-Pressure Respiration Pulmonary Surfactants Budesonide/TU

Received: 19 May 2020

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R725.638

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2021.07.004 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2021/V38/I7/975

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