Abstract【Objective】 To study the correlation between serum and colonic mucosal IL-10, TNF-α, tyrosin (PYY) and sealin-1 in different types of irritable bowel syndrome (IBS). 【Methods】 The data of 90 patients with IBS, according to the symptomatic types, were divided into the diarrhea group (n=50) and the constipation group (n=40). In the same period, 40 healthy people were selected as the control group. The levels of serum and colonic mucosa IL-10, TNF-α, tyrosin and sealin-1 were compared among the three groups. The correlation of IL -10,TNF-α, PYY and sealin-1 in colonic mucosal and serum was analyzed. 【Results】 Levels of IL-10 and sealin-1 in the control group were higher, while levels of TNF-α and PYY in the control group were lower than those in the diarrhea group (P<0.05). IL-10 and sealin-1 levels in the diarrhea group were lower than those in the constipation group; and TNF-α and PYY levels in the diarrhea group were higher than those in the constipation group (P<0.05). There was no significant difference in TNF-α level between the control group and the constipation group (P>0.05). The positive expression rates of IL-10 in the colonic mucosa of the control group, diarrhea group and constipation group were 37.50% (15/40), 24.00% (12/50), and 55.00% (22/40), respectively; The difference was statistically significant (P<0.05). The positive expression rate of TNF-α in the colonic mucosa of the control group was 22.50% (9/40), which was significantly lower than that in the diarrhea group by 68.00% (34/50) (P<0.05). the positive expression rate of PYY in the colonic mucosa of the control group was 27.50% (11/40), which was significantly lower than that in the diarrhea group (76.00%, 38/50) (P<0.05). The positive expression rates of sealin-1 in the colonic mucosa of the control group, diarrhea group and constipation group were 32.50% (13/40), 14.00% (7/50), 75.00% (30/40), respectively; The difference between the three groups was statistically significant (P<0.05). The positive expression rate of TNF-α and PYY in the colonic mucosa of the control group was not statistically significant compared to the constipation group (P>0.05). There was no correlation between IL-10 and PYY in serum and colonic mucosa of IBS (P>0.05), and the serum sealin-1 level was positively correlated with colonic mucosal sealin-1 level (P<0.05). TNF-α in serum and colonic mucosa of patients with IBS were positively correlated with PYY (P<0.05), but not correlated with sealin-1 (P>0.05). 【Conclusion】 In patients with IBS, there is an imbalance between anti-inflammatory factors and pro-inflammatory factors. It can prevent or control the development of IBS by regulating the expression of PYY and sealin-1, thereby reducing the inflammatory response and promoting clinical efficacy.
ZHU Wei-fang,CAI Zhi-jun. Correlation Analysis Between Serum and Colonic Mucosal IL-10,TNF-α,Tyrosin and Sealin-1 in Different Types of Irritable Bowel Syndrome[J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(5): 727-730.
2021, Vol. 38 
