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| Diagnostic Value of Serum miR-122 Level in the Degree of Liver Fibrosis in Patients with Chronic Hepatitis C |
| JIA Xue-you, ZANG Xiao-qing |
| Xi'an Central Hospital, Xi'an Shaanxi, 710003 |
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Abstract 【Objective】To explore the diagnostic value of serum microRNA-122 level in the degree of liver fibrosis in patients with chronic hepatitis C (CHC). 【Methods】One hundred and twenty patients with chronic hepatitis C in our hospital were enrolled. qRT-PCR was used to detect the expression of serum microRNA-122. The receiver operating characteristic (ROC) was used to evaluate the predictive value of microRNA-122 in the diagnosis of liver fibrosis in patients with chronic hepatitis C. 【Results】There were 62 males and 58 females with an average age of 46.91 ± 17.26 years.The levels of alanine aminotransferase(ALT)and aspartate aminotransferase (AST) were 72.85±21.34 U/L and 76.3±18.43 U/L, respectively.The expression level of miR-122 was 1.63±0.57, and the score of AST and platelet ratio index (APRI) was 1.42±0.52.Liver biopsy showed that there were 37/41/28/14 cases of liver fibrosis grade 1/2/3/4.According to the degree of liver fibrosis, the patients were divided into two groups: S1-2 group and S3-4 group. The levels of AST, alt, miR-122 and inflammatory activity in S3-4 group were significantly higher than those in S1-2 group ( P <0.05), but there was no significant difference in age, gender and APRI score between the two groups ( P >0.05).MiR-122 predicted that the best critical point of s3-4 fibrosis severity in CHC patients was 1.76.At this time, the predictive sensitivity of miR-122 was 78.91%, the specificity was 98.83%, and the area under the curve AUC was 0.940.【Conclusion】Serum microRNA-122 have diagnostic value for the severity of liver fibrosis in patients with CHC.
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Received: 11 November 2019
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2021, Vol. 38 
