Abstract 【Objective】To investigate the dynamic changes of C-reactive protein (CRP) to hemoglobin (Hgb) ratio (CRP/Hgb), erythrocyte sedimentation rate (ESR) and galactose lectin-3 (Gal-3) in patients with acute infective endocarditis (AIE).【Methods】A total of 147 patients with AIE was selected. According to the survival within 1 month after admission, they were divided into death group (n=23) and survival group (n=124). The levels of CRP/HGB, ESR, Gal-3, white blood cell count (WBC) and procalcitonin (PCT) were compared between the two groups before treatment, 1 week after treatment and 2 weeks after treatment. The relevant influencing factors of prognosis were analyzed by logistic regression equation, and the working characteristic curve of subjects was used (ROC) the prognostic value of each index was analyzed. 【Results】 After 1 and 2 weeks of treatment, the levels of serum CRP/HGB, ESR, Gal-3, WBC and PCT in the death group were not significantly different from those before treatment (P>0.05); the above indexes in the survival group were lower than those before treatment, and the death group was higher than that in the survival group (P<0.05). Logistic regression equation analysis showed that the levels of CRP/HGB, ESR and Gal-3 after 1 and 2 weeks of treatment were related factors affecting the prognosis of patients (P<0.05). The AUCs of CRP/HGB, ESR and Gal-3 after 2 weeks of treatment were 0.827, 0.844 and 0.836 respectively (P<0.05), and the AUC of CRP/HGB+ESR+Gal-3 was 0.949 (P<0.05). 【Conclusion】 Monitoring the levels of CRP/HGB, ESR and Gal-3 during treatment is of great significance to evaluate the prognosis of AIE patients, and can assist in predicting the prognosis of AIE patients.
WANG Ying,YANG Kun,HE Yong. Dynamic Changes of CRP/HGB, ESR and Gal-3 in Patients with Acute Infective Endocarditis during Treatment[J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(12): 1815-1817.
[1] NAKATANI S, OHARA T, ASHIHARA K, et al. Japanese Circulation Society Joint Working Group. JCS 2017 Guideline on Prevention and Treatment of Infective Endocarditis[J].Circ J,2019,83(8):1767-1809.
[2] ARQUES S. Human serum albumin in cardiovascular diseases[J].Eur J Intern Med,2018,52(1):8-12.
[3] 冯强,吕凡芹.黄连解毒汤合五味消毒饮治疗急性感染性心内膜炎的临床效果[J].世界中医药,2020,15(14):2138-2141.
[4] ZHONG X,QIAN X,CHEN G,et al.The role of galectin-3 in heart failure and cardiovascular disease[J].Clin Exp Pharmacol Physiol,2019,46(3):197-203.
[5] 杨天伦,钟巧青,倪国华,等.AHA关于成人感染性心内膜炎诊断、抗菌治疗以及并发症的处置的科学声明解读[J].中国循环杂志,2016,31(z2):28-33.
[6] 张亚平,侯激流,张军,等.感染性心内膜炎患者病原菌分布及心功能指标与感染相关指标表达研究[J].中华医院感染学杂志,2017,27(6):1251-1254.
[7] MORIYA J. Critical roles of inflammation in atherosclerosis[J].J Cardiol,2019,73(1):22-27.
[8] 黄伟雄.中药敷脐配合小儿推拿治疗小儿腹泻106例临床观察[J].湖南中医杂志,2019,35(1):58-59.
[9] SREJOVIC I,SELAKOVIC D,JOVICIC N,et al.Galectin-3: roles in neurodevelopment, neuroinflammation, and behavior[J].Biomolecules,2020,10(5):798.
[10] 刘新娣.血必净注射液联合磷酸肌酸钠对感染性心内膜炎患儿心肌功能的影响[J].淮海医药,2019,37(5):469-471.
[11] 丁亚楠,衡紫薇,张雅男,等.左卡尼汀与头孢替唑钠对感染性心内膜炎患者血清肌钙蛋白与PCT及ESR水平的影响[J].抗感染药学,2019,16(4):709-712.
[12] 曾德菲,邢孔玉,邓靖,等.感染性心内膜炎继发医院感染病原学及其影响因素研究[J].中华医院感染学杂志,2019,29(7):1031-1034.
2021, Vol. 38 
