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| Efficacy of Recombinant Human Endostatin Combined with NP Regimen in Treatment of Recurrent and Metastatic Nasopharyngeal Carcinoma |
| CHEN Qi, CHEN Xuan, YOU Lan, et al |
| Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200011 |
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Abstract 【Objective】To explore the clinical efficacy of recombinant human endostatin (ES) combined with NP regimen (vinorelbine+cisplatin) in the treatment of recurrent and metastatic nasopharyngeal carcinoma. 【Methods】A total of 82 patients with recurrent and metastatic nasopharyngeal carcinoma admitted to Shanghai Shuguang Hospital were selected as the research objects. According to the treatment plan, they were divided into the observation group and the control group. There were 40 patients in the control group who were treated with a single NP regimen, while 42 patients in the observation group were treated with NP regimen combined with ES. Both groups of patients were evaluated for efficacy and adverse drug reactions after 4 cycles of treatment. The 1-year survival rate of the two groups of patients was followed-up and recorded. 【Results】The disease control rate of the observation group was 90.47%, which was higher than that of the chemotherapy group (70.00%) (P<0.05). Most patients in the two groups had mild adverse reactions of grade I to II. There was no significant difference in the incidence of various adverse reactions in the two groups (P>0.05). In the control group, 21 patients died and the 1-year survival rate was 47.50% with the survival period of 4 to 8 months. While 13 patients died in the observation group showing he 1-year survival rate was 69.05%with the survival period was 7 to 11 months. There was a statistically significant difference in survival curves between the observation group and the control group (P<0.05). 【Conclusion】ES combined with NP regimen for patients with recurrent and metastatic advanced nasopharyngeal carcinoma can effectively improve the patient's disease control rate, prolong the patient's life cycle and have good safety.
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Received: 18 August 2021
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2021, Vol. 38 
