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| Analysis of Short-term Effects on Preoperative Neoadjuvant Chemotherapy for Total Mesentery Excision in Patients with Middle and Low Rectal Cancer |
| SONG Zhong-xue, ZHENG Shao-hua |
| Department of General Surgery, The Second Hospital of Weinan, Weinan 714000 |
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Abstract 【Objective】To observe the short-term effect of preoperative neoadjuvant chemotherapy in improving total mesentery excision for patients with mid-low rectal cancer. 【Methods】A total of 153 patients with mid-low rectal cancer treated in our hospital were retrospectively analyzed. 96 patients underwent open total mesorectal excision (control group), 57 patients underwent neoadjuvant chemotherapy (observation group) before surgery, and then underwent open total mesorectal excision. The perioperative situation, surgical treatment effect, serological indexes and survival conditions of the two groups were compared. 【Results】There was no significant difference between the two groups in operation time, intraoperative blood loss, postoperative first exhaust time, postoperative first defecation time, feeding fluid time, postoperative hospital stay and postoperative complication rate (P>0.05). The anus-preserving rate in the observation group was significantly higher than that in the control group (P<0.05).Before treatment, there was no significant difference in serum CEA, CA19-9 and CA125 between the two groups. After operation, the level of each index decreased significantly (P<0.05), and the improvement in the observation group was more obviously(P<0.05).There was no significant difference in CD3+, CD4+ and CD4+/CD8+ between the two groups before treatment. The levels of various indexes after operation were significantly increased (P<0.05), and the improvement in the observation group was more obvious (P<0.05).There was no significant difference between the two groups in the length of proximal end, distal end, distant metastasis and mean survival time (P<0.05), The number of lymph nodes detected in the observation group was significantly lower than that in the control group (P<0.05). 【Conclusion】 Preoperative neoadjuvant chemotherapy can significantly improve anus-preserving rate, reduce the value of CEA, CA19-9 and CA125, and improve the body's immune function. It has definite curative effect and is worthy of clinical application.
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Received: 06 August 2019
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2021, Vol. 38 
