红花注射液联合肢体康复疗法治疗脑梗死患者的疗效及对血清炎症因子的影响

doi:10.3969/j.issn.1671-7171.2020.08.017

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Abstract 【Objective】 To investigate the curative effect of safflower injection combined with limb rehabilitation therapy in the treatment of cerebral infarction and its influence on serum inflammatory factors.【Methods】 One hundred and twelve patients with cerebral infarction in our hospital from September 2015 to may 2017 were selected and randomly divided into observation group and control group. The control group was given routine rehabilitation treatment, while the observation group was treated with Safflower Injection on the basis of the control group. The clinical efficacy, hemodynamic changes and serum inflammatory factor levels of the two groups were compared.【Results】 The clinical total effective rate of the observation group was 92.86%, significantly higher than 78.57% of the control group, the difference was statistically significant (χ2=4.667, P<0.05); after treatment, the Fugl Meyer Rating Scale (FMA) score and Barthel Index (BI) score of the observation group were significantly higher than those of the control group, and the NIHSS score was significantly lower than that of the control group (P<0.05) The blood high shear viscosity, low shear viscosity and plasma viscosity of the observation group were significantly lower than those of the control group, and the maximum peak flow velocity and vascular resistance index of bilateral middle cerebral arteries were significantly higher than those of the control group, and the difference was statistically significant (P<0.05); after treatment, the levels of serum high-sensitivity C-reactive protein (hs CRP) and central nerve specific protein (S100 β protein) in the observation group were significantly lower than those in the control group The levels of vascular endothelial growth factor (VEGF) and transforming growth factor-β1(TGF-β 1) in the two groups were significantly higher than those in the control group (P<0.05); there was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).【Conclusion】 On the basis of conventional rehabilitation therapy, safflower injection can effectively improve the clinical efficacy of patients with cerebral infarction, improve the blood flow status of patients, and reduce the level of serum inflammatory factors, which is worthy of clinical application.

Key words： Brain Infarction Inflammation Mediators/BL Extremities Rehabilitation

Received: 07 March 2018

PACS:

R743.33

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	Articles by authors
	XIAO Lin-ting
	ZHOU Hui
	ZHOU Jing-xia

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XIAO Lin-ting,ZHOU Hui,ZHOU Jing-xia. Effect of Safflower Injection Combined with Limb Rehabilitation Therapy in the Treatment of Cerebral Infarction and its Influence on Serum Inflammatory Factors[J]. JOURNAL OF CLINICAL RESEARCH, 2020, 37(8): 1174-1177.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2020.08.017 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2020/V37/I8/1174

[1] 袁凤云,刘玉梅,孙科远,等.丹参多酚酸盐对脑梗死患者脑血流动力学的影响分析[J].中国煤炭工业医学杂志,2015,18(6):895-898.
[2] 吴婧.丹红注射液联合康复锻炼针灸治疗对脑梗死患者脑血流动力学的影响及疗效[J].中国实用神经疾病杂志,2015,18(3):75-76.
[3] Bonaventura A , Liberale L, Vecchié A ,et al. Update on in-flammatory biomarkers and treatments in ischemic stroke[J].Int J Mol Sci,2016,17 (12):1967.
[4] 马玉海.丹红注射液联合中医康复疗法治疗急性脑梗死45例[J].中国中医药,2014,12(11):38-39.
[5] Arevalo-Lorido JC, Carretero-Gomez J, Fernandez-Recio JM, et al. Lowering C-reactive protein with statins after an is-chemic stroke avoids mortality and readmissions. a prospec-tive cohort study[J].Ann Med,2015,47(3): 226-232.
[6] 张阿宁.hs-CRP、FIB 检测对脑梗死患者的意义[J].检验医学与临床, 2016,13(17): 2453-2454.
[7] Mahoney FI, Barthel DW.Functional evaluation: the barthel index[J].Md State Med J,1965, 14: 61-65.
[8] Gladstone DJ, Danells CJ, Black SE. The fugl-meyer assessment of motor recovery after stroke: a critical review of its measurement properties[J].Neurorehabil Neural Repair,2002,16(3):232-240.
[9] Adams HP Jr, Davis PH, Leira EC, et al. Baseline NIH Stroke Scale score strongly predicts outcome after stroke: A report of the Trial of Org 10172 in Acute Stroke Treatment (TOAST)[J].Neurology,1999, 53(1):126-131.
[10] 全国第4 届脑血管病学术委员会.脑卒中临床神经功能缺损程度评分标准(1995)[J].中华神经科杂志,1996,29(6):381-383.
[11] Chehaibi K ,Trabelsi I, Mahdouani K , et al. Correlation of ox-idative stress parameters and inflammatory markers in is-chemic stroke patients[J].J Stroke Cerebrovasc Dis,2016, 25(11):2585-2593.
[12] Li LJ, Li YM, Qiao BY, et al. The value of safflower yellowin-jection for the treatment of acute cerebral infarction: a ran-domized controlled trial [J].Evid Based Complement Alternat Med,2015,2015:478793.
[13] 时钦.红花黄色素对急性脑梗死患者血液流变学影响的 Meta 分析[J].上海中医药杂志,2016,50(9):18-22.
[14] 廖梓亘,陈慧.红花注射液在大鼠脑缺血/再灌注损伤中抗氧化作用的研究[J].当代医学, 2015,21(35):6-8.
[15] 李千红,刘瑞,卢秀萍.康复治疗对老年重型颅脑损伤患者肢体运动功能和日常生活能力的影响[J].中国老年学杂志,2012,32(16):3402-3404.
[16] 吉智,范秀博.注射用红花黄色素联合阿加曲班治疗急性脑梗死的临床研究[J].现代药物与临床,2016,31(2):158-162.
[17] He J, Kwon Y, Li C, et al.Several considerations in using tradi-tional Chinese patent medicine for cerebral infarction[J].Chin J Integr Med(Engl),2012,18(8):571-574.
[18] 魏艳霞.红花注射液联合康复治疗对老年脑梗死患者的临床疗效观察[J].中国临床药理学杂志,2016,32(7):585-587,590.
[19] 路小薇.急性脑梗死患者血清炎性因子及血流动力学变化及意义[J].海南医学院学报,2016,22(1):93-95.
[20] KIM J, SONG T J, SONG D, et al. Serum alkaline phosphatase and phosphate in cerebral atherosclerosis and functional outcomes after cerebral infarction [J].Stroke,2013, 44(12):3547-3549.
[21] Dwedar AZ.Sonothrombolysis in acute middle cerebral artery stroke[J].Neurol India,2014,62(1): 62-65.
[22] 秦秀德.红花注射液通过抗炎症反应治疗急性脑梗死的机制研究[J].中国中医急症,2017,26(3):409-411,459.
[23] Ono H, Nishijima Y, Ohta S, et al. Hydrogen gas inhalation treatment in acute cerebral infarction: a randomized controlled clinical study on safety and neuroprotection[J].J Stroke Cerebrovasc Dis,2017,26(11):2587-2594.