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| Correlation between Serum Alkaline Phosphatase and Coronary Artery Calcification |
| YU Jia-yu, BAO Rong-qi |
| Suzhou Hospital of Traditional Chinese medicine, Jiangsu Suzhou 215009 |
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Abstract 【Objective】 To explore the relationship between serum alkaline phosphatase and coronary artery calcification. 【Methods】 A total of 154 hospitalized patients underwent 128-layer coronary artery CT scan in Suzhou traditional Chinese Medicine Hospital. According to the coronary artery CT calcification score, the severity of coronary artery calcification was evaluated, and the serum alkaline phosphatase level was measured. The patients were divided into calcified group and non-calcified group according to the calcification score. The clinical data and ALP level of the patients in the two groups were compared, and the correlation between coronary artery calcification score and serum ALP level, age and blood lipid index in the calcified group was further analyzed.【Results】 There were significant differences in age, smoking history, diabetes mellitus history, hypertension history and serum high density lipoprotein cholesterol (HDL-C) and ALP levels between calcification group and non calcification group (P<0.05); there were no significant differences in gender, drinking history, serum total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), triglyceride (TG) (P>0.05).In calcification group, calcification score was significantly positively correlated with age and ALP (P<0.01), and negatively correlated with HDL-C(P=0.016<0.05), but there was no correlation between calcification score and TC, TG, LDL-C (P>0.01).【Conclusion】 Serum alkaline phosphatase level is closely related to coronary artery calcification, which can be used as a biological index for the diagnosis of coronary artery calcification.
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Received: 24 March 2020
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[1] Hwilliam S,Takehiro N, Navneet N,et al.Vascular calcifification: the evolving relationship of vascular calcifification to major acute coronary events[J].J Nuclear Med,2019,60(9):1207-1212.
[2] Cecilia HL,Barbro ER,Michae K,et al.Bone alkaline phosphatase and tartrate-resistant acid phosphatase: potential co-regulators of bone mineralization[J].Calcif Tissue Int,2017,101(1): 92-101.
[3] Daniel A,Sergio G, Ricardo VB.Tissue non-specific alkaline phosphatase and vascular calcification: a potential therapeutic target[J].Curr Cardiol Rev,2019,15(2):91-95.
[4] Agatston AS,Janowitz WR,Hildner FJ,et al.Quantification of coronary artery calcium using ultrafast computed tomography[J].J Am Coll Cardiol,1990, 15:827-832.
[5] Tsao CW, Pencina KM,Massaro JM,et al.Cross-sectional relations of arterial stiffness,pressure pulsatility,wave reflection,and arterial calcification[J]. Arterioscler Thromb Vasc Biol,2014,34(11): 2495-2500.
[6] Azpiazu D,Gonzalo S,Villa-bellosta R.Tissue non-specific alkaline phosphatase and vascular calcification:a potential therapeutic target[J].Curr Cardiol Rev,2019,15(2):91-95.
[7] Terao Y,Satomi-kobayashi S,Hirata K.et al.Involvement of Rho-associated protein kinase (ROCK) and bone morphogenetic protein-binding endothelial cell precursor-derived regulator (BMPER) in high glucose-increased alkaline phosphatase expression and activity in human coronary artery smooth muscle cells[J].Cardiovasc Diabet,2015,14(12):104.
[8] Romanelli F,Corbo A, Salehi M,et al.Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelial cells accelerates coronary artery disease in a mouse model of familial hypercholesterolemia[J].PLoS One,2017,12(10):e0186426.
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2020, Vol. 37 
